Selegiline enhances...
 
Notifications
Clear all

Selegiline enhances erectile activity


pSimonkey
(@psimonkey)
Estimable Member
Joined: 3 years ago
Posts: 110
Topic starter  

Selegiline enhances erectile activity induced by dopamine injection
in the paraventricular nucleus of the hypothalamus in anesthetized rats
by
Allard J, Bernabe J, Derdinger F, Alexandre L, McKenna K, Giuliano F.
PELVIPHARM Laboratories, Domaine INRA, Bures-sur-Yvette, France.
Int J Impot Res 2002 Dec;14(6):518-22

ABSTRACT

Apomorphine delivered in the paraventricular nucleus of the hypothalamus (PVN) induces penile erection in rats, suggesting a role of dopaminergic projection to the PVN in the control of penile erection. We assessed whether the selective inhibitor of monoamine oxidase B, selegiline, could enhance the erectile activity induced by dopamine delivery in the PVN. Intracavernous and blood pressure (ICP and BP) were monitored in anesthetized rats to quantify ICP rises (number and percentage of ICP maximum/mean BP (ICPmax/BPx100)) elicited by 10 micro g dopamine injection in the PVN after saline or 3 mg/kg i.v. selegiline (8 rats per group). The number of ICP rises (mean+/-s.d.: 4.5+/-2.9 vs 1.4+/-1.9; P=0.017) and their ICPmax/BPx100 (49+/-8% vs 34+/-9%; P=0.015) were significantly greater upon dopamine injection in the PVN than upon vehicle. Compared to saline i.v., 3 mg/kg selegiline pretreatment significantly increased the number of ICP rises induced by dopamine injection in the PVN (9.4+/-2.6 vs 4.5+/-2.9; P<0.001), without affecting their amplitude. This suggests that drugs potentiating dopaminergic responses in the central nervous system might enhance proerectile commands of supraspinal origin.


Quote
Seabiscuit Hogg
(@seabiscuit-hogg)
Reputable Member
Joined: 3 years ago
Posts: 455
 

Interesting.

Seabiscuit Hogg is a fictious internet character. It is not recommended that you receive medical advice from fictious internet characters.

SBH :)


ReplyQuote
pSimonkey
(@psimonkey)
Estimable Member
Joined: 3 years ago
Posts: 110
Topic starter  

I often think that selegiline is much overlooked as a very useful PCT addition, as well as the great many other qualities that it can bring to overall health and vitality.


ReplyQuote
Share: