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ARBs downsize adipocytes in VF.


oswaldosalcedo
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Am J Hypertens. 2007 Apr;20(4):431-6.

Angiotensin II receptor blockers downsize adipocytes in spontaneously type 2 diabetic rats with visceral fat obesity.

Mori Y, Itoh Y, Tajima N.

Department of Internal Medicine, National Hospital Organization, Utsunomiya National Hospital, Kawachi-gun, Tochigi, Japan.

OBJECTIVE: To investigate the influence of blockade of the renin-angiotensin system (RAS) on adipocytes, we compared the effect of telmisartan versus valsartan and amlodipine on adipocyte cellularity in the spontaneously type 2 diabetic, obese rat model. METHODS: Male Otsuka Long Evans Tokushima Fatty rats, 8-week-old, were divided into four groups as follows: valsartan (V) group (10 mg/kg, n = 12), telmisartan (T) group (5 mg/kg, n = 12), amlodipine (A) group (2 mg/kg, n = 12), and control (C) group (n = 12). Each drug was mixed with chow and given for 16 weeks. RESULTS: Although no significant differences were observed in the fasting plasma glucose level between the groups, the fasting plasma insulin level for group T was significantly lower than that for group C. Histopathologic examination showed that the ratio of small adipocytes in groups V and T was significantly higher than that in group C, with the ratio of large adipocytes and the mean adipocyte size shown to be significantly lower in groups V and T than in group C. Furthermore, group T was shown to have a significantly higher ratio of small adipocytes, a significantly lower ratio of large adipocytes, as well as a significantly lower mean adipocyte size, compared to group V. CONCLUSIONS: Although both valsartan and telmisartan downsized adipocytes, adipocyte downsizing was significantly greater with telmisartan compared to valsartan. The likely mechanism for this difference was thought to be the PPAR-gamma-mediated action of telmisartan.

dr frankenstein


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jboldman
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i have always found it interesting that ppar gamma results in lipogenisis however adipocyte size is greatly reduced.

jb


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madspin
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You guys really know how to make a guy feel dumb


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neworleansgt
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I second that. IT seems like its always a 2 man conversation

i was the 1997 International Spelling Bee Winnur


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jboldman
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its not really that complicated. but we will try to expain a little better in the future.

jb


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madspin
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Posted by: jboldman
its not really that complicated. but we will try to expain a little better in the future.

jb

I was just ragging you guys, though I admit, I get lost. I end up trying to look for a thumbs up or down from you......kinda like cliffs notes


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jboldman
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i usually try to chime in but dr.f did good job explaining.

jb


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neworleansgt
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Yea, I usually skip to the conclusion portions LOL

i was the 1997 International Spelling Bee Winnur


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