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Cortisol, Atrophy and impaired muscle protein synthesis


oswaldosalcedo
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J Clin Endocrinol Metab. 2006 Sep 19

Atrophy and impaired muscle protein synthesis during prolonged inactivity and stress.

Paddon-Jones D, Sheffield-Moore M, Cree MG, Hewlings SJ, Aarsland A, Wolfe RR, Ferrando AA.

Departments of Surgery, Internal Medicine and Anesthesiology, The University of Texas Medical Branch, Galveston, Texas, 77550.

Context: We recently demonstrated that 28 days of bedrest in healthy volunteers results in a moderate loss of lean leg mass and strength. Objective: To quantify changes in muscle protein kinetics, body composition and strength during a clinical bedrest model reflecting both physical inactivity and the hormonal stress response to injury or illness. Design: Muscle protein kinetics were calculated during a primed, continuous infusion (0.08 micromol*kg(-1)*min(-1)) of (13)C6 - phenylalanine on Day 1 and 28 of bedrest. Setting: The General Clinical Research Center at the University of Texas Medical Branch. Participants: Healthy male volunteers (n = 6; 28 +/- 2 y; 84 +/- 4 kg; 178 +/- 3 cm). Intervention: During bedrest, hydrocortisone sodium succinate was administered intravenously (Day 1 and 28) and orally (Days 2-27) to reproduce plasma cortisol concentrations consistent with trauma or illness ( approximately 22 microg/dL). Main outcome measures: We hypothesized that inactivity and hypercortisolemia would reduce lean muscle mass, leg extension strength and muscle protein synthesis. Results: Volunteers experienced a 28.4 +/- 4.4% loss of leg extension strength (P = 0.012) and a 3-fold greater loss of lean leg mass (1.4 +/- 0.1 kg), (P = 0.004) compared with our previous bedrest-only model. Net protein catabolism was primarily due to a reduction in muscle protein synthesis (FSR: 0.081 +/- 0.004 (Day 1) vs. 0.054 +/- 0.007%/h (Day 28), P = 0.023). There was no change in muscle protein breakdown. Conclusion: Prolonged inactivity and hypercortisolemia represents a persistent catabolic stimulus that exacerbates strength and lean muscle loss via a chronic reduction in muscle protein synthesis.

dr frankenstein


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guijr
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So we don't wanna get sick and in bed for a long time. But if so, then we have to be provided with bed strength training even during bed rest.

"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.


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oswaldosalcedo
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Posted by: guijr
So we don't wanna get sick and in bed for a long time. But if so, then we have to be provided with bed strength training even during bed rest.

.......or have high cortisol levels like me.

dr frankenstein


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jboldman
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why would high cortisol levels be a good thing?

jb


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guijr
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I'm not him, but I guess he has a condition called Hypercortisolemia.

"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.


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jboldman
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i woud guess as well but the way he said it implied that it would alleviate some of the bad side effects of extended bed rest.

jb


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oswaldosalcedo
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Posted by: jboldman
i woud guess as well but the way he said it implied that it would alleviate some of the bad side effects of extended bed rest.

jb

no,i suffer mild hypercortisolemia,is very difficult for me,put on me, muscles.

Posted by: guijr
I'm not him, but I guess he has a condition called Hypercortisolemia


correct!

imo:
hardgainer=
high cortisol levels.
very low estradiol levels.
low testoterone.
thin bones.
of course,can exist, other factors.

dr frankenstein


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