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Maybe I am not made for testesterone

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MrAnderson
(@mranderson)
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Joined: 5 years ago
Posts: 34
Topic starter  

Damn it. Last time (the first time) I took test e 4 months ago I got real bad eye pressure and a terrible headache that lasted for over a week. I figured that it was bad aas.
Now I Have completely diff test e and I am experiencing the same problem.
First injection was 24 hours ago and today I am starting to feel the eye pressure. I only took 250mg in the glute. Clean injection, aspirated, etc.
Maybe I just wasnt meant to do test.... But it is naturally in my system. Is there a bid difference between my body's natural test and test e. I only took 250mg (1/2 mL) so hopefully the pain is not as bad as last time.
Normally I am very healthy.
Is there a medical condition or some reaction that I could be having to the test or it's ester/suspension.
The pain only occurs around one eye and gets worse as I do strenuous activity.


   
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jboldman
(@jboldman)
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Posts: 1450
 

this is very strange, for some reason it sounds like you are getting an increase in intra-ocular pressure. have you taken you bp lately?

jb


   
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ready2explode
(@ready2explode)
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Posts: 404
 

Strange indeed...and I have no idea how to help.

"In any contest between power and patience, bet on patience."
~W.B. Prescott

"Only two things are infinite, the universe and human stupidity, and I'm not sure about the former."
~Albert Einstein


   
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MrAnderson
(@mranderson)
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Joined: 5 years ago
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Topic starter  

i wrote down the wrong dosage, only 125mg in the glute.
I will check my bp today. last time it happened it was still in the normal range. its weird because when i am sleeping it completely goes away, but after i get up and start to move about it comes back. last time it got so bad i just laid down for the better part of the week and the affects slowly went away each day.
I also developed a cough last time. feels like i am getting one now too.
i'm glad i only did 125 mg this time, maybe the pressure can be manageable.


   
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guijr
(@guijr)
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Joined: 6 years ago
Posts: 801
 

Bro, you should see a doc. ASAP if you really want to use Test to find out if you have a condition. Sorry to hear that. Good luck.

"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.


   
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liftsiron
(@liftsiron)
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Posts: 507
 

Bro imo it's clear from past posts of yours that you are a hypochondriac and regardless of what you use you are going to believe that you suffer strange aliments. Best course of action would be to cease all aas use.

liftsiron is a fictional character and should be taken as such.


   
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MrAnderson
(@mranderson)
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Topic starter  

I am not a hypo. I was just trying to shed some humor on my misfortune.
I went to the eye doc today. All of my symptoms matched that of closed-angle glaucoma. They did a bunch of tests and said my eyes are healthy and I dont have that condition. They recommended that I see a regular doc and said it may be a sinus infection. I didnt mention any of the aas until they told me their recomendation, and they said it was out of their scope to determine if that was the cause.
So I'll see a doc and hopefully this can shed some light on it. I really don't want to be thought of as a hypochondriac. I havent been to a doctor in over 10 years and live a healthy life. It's just that this pain is so bad I see no other alternative.
I'd be jumping to conclusions to start guessing but maybe I am having a reaction to this particular testesterone ester. I just come here for some sound advice because IMO this is the best place to get it from. I dont want to come off like a panzy but I was just desperate for some advice from the best source I know on the subject.


   
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liftsiron
(@liftsiron)
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Posts: 507
 

I was joking with you bro. But there isn't any possible way that 125mgs of test shot in the glute withing 24 hours would have any effect, especially causing pressure in the eyes. I was concerned that you may have had glaucoma, it's very good that you don't. My sinus suck!!! And when I have a sinus infection, I often feel extreme pressure in my eyes as well as my teeth hurt. Best of luck to you.

liftsiron is a fictional character and should be taken as such.


   
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guijr
(@guijr)
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Posts: 801
 

With all respect, really no offence, that conversation between you guys was hilarious (LOL), I mean that hypo thing, peace.

Now serious, docs always have some good info to give to us, I really admire them, my ex-wife is a doc and she rules.

"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.


   
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MrAnderson
(@mranderson)
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Topic starter  

Lifts I have been reading CEM posts daily for the past 5 months. I really respect your advice and posts. If I were as knowledgeable about this stuff as you and read about someones repeated failure I'd tell them to stop too... But I am DETERMINED to figure out a way to do a good cycle. It'd be a shame to learn so much and have to file it away into the useless info bin because I can't utilize it.

3 days later I fell 80% back to normal. This puzzles everyone I know who has done aas. I am trying to narrow down the possibilities. I figure it can't be infection related because it comes on too fast and go away without antibiotics. I know its dose related because the smaller dose caused less of a reaction this go around. I also figure that it is not the Testosterone because I have that in me naturally. So maybe it's either the oil or the ester. The oil in this brand was from grape seeds and the last time it was peach oil. Same reaction to both? Maybe it's the ester.
The pain is gone now so I don't see too much reason to go to a doc. I couldnt imagine them telling me anything other than not to do aas...
I have been told that Test Cyp is closer to the natural test in the body. Is this true?
What would you guys do if you were in my shoes. Recommendations?


   
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 Mark
(@mark)
Active Member
Joined: 6 years ago
Posts: 5
 

Maybe it's a reacion to the BA


   
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bear
 bear
(@bear)
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Joined: 6 years ago
Posts: 33
 

I'm with Mark: an alergic reaction to BA or BB would be my guess, as well. A shot of Test Suspension would confirm/disprove the theory, I should think. (Although it isn't something that folks normally start AAS experimentation with, so perhaps not such a good idea.)

I wouldn't worry about the specific ester you are using, as endogenous test is unestrified, so enanthate and cypionate are equally "unnatural."


   
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oswaldosalcedo
(@oswaldosalcedo)
Estimable Member
Joined: 6 years ago
Posts: 243
 
Posted by: MrAnderson
But I am DETERMINED to figure out a way to do a good cycle. It'd be a shame to learn so much and have to file it away into the useless info bin because I can't utilize it.

3 days later I fell 80% back to normal. This puzzles everyone I know who has done aas. I am trying to narrow down the possibilities.

People can also have elevated pressures without signs of optic nerve damage or vision loss. They are considered to be at risk for glaucoma because of the elevated intraocular pressure. In medical terms, these people are known as glaucoma suspects or ocular hypertensives.
can be a pre open-angle glaucoma.

-------------------

Exp Eye Res. 2006 Jun;82(6):1053-9.

Androgen receptor and NFkB expression in human normal and glaucomatous optic nerve head astrocytes in vitro and in experimental glaucoma.

Agapova OA, Kaufman PL, Hernandez MR.

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA.

For several decades, clinical and experimental observations suggested a relationship between steroids and glaucoma; however, the possibility that androgens are also involved in the glaucomatous changes in the optic nerve heads (ONH) has not been explored. Our previous findings that glaucomatous ONH astrocytes synthesize androgen-metabolising enzymes and overproduce a neuroactive androgen, 5alpha-androstane-3alpha, 17beta-diol (3alpha-diol) led us to propose that ONH astrocytes are androgen target cells. Androgens modulate different cellular processes through androgen receptor (AR). NFkB is a transcription factor that positively regulates AR transcription. Here, we analysed AR and NFkB expression in normal and glaucomatous ONH astrocytes in vitro, and in vivo in a monkey model of experimental glaucoma (ExpG) by quantitative real time RT-PCR, Western blotting and immunohistochemistry. We demonstrated that in vitro human glaucomatous ONH astrocytes express AR mRNA and protein at higher levels than normal astrocytes and that in vivo ONH astrocytes from eyes with ExpG showed increased nuclear and cytoplasmic AR immunostaining compared to control eyes. In the retina, retinal ganglion cells (RGC) demonstrated cytoplasmic staining both in control and in ExpG eyes. NFkB mRNA expression was higher in glaucomatous ONH astrocytes than in normal and more nuclear NFkB protein was detected in glaucomatous ONH astrocytes. In vivo immunopositive NFkB nuclear staining of ONH astrocytes in ONH and in RGC in retina was detected both in control and in ExpG eyes. We conclude that in addition to our published data, increase of AR and NFkB expression in glaucomatous ONH astrocytes provides strong evidence that androgens play a significant role in the pathophysiology of glaucoma.

J Neurochem. 2006 Jul;98(2):355-63.

A neuroactive steroid 5alpha-androstane-3alpha,17beta-diol regulates androgen receptor level in astrocytes.

Agapova OA, Malone PE, Hernandez MR.

Department of Ophthalmology and Visual Sciences, Washington University, School of Medicine, Saint Louis, Missouri 63110, USA.

Optic nerve head (ONH) astrocytes from patients with glaucomatous optic neuropathy exhibit increased production of 5alpha-androstane-3alpha,17beta-diol (3alpha-diol), a neuroactive metabolite of 5alpha-dihydrotestosterone (5alpha-DHT). To determine whether ONH astrocytes are androgen target cells, and whether 3alpha-diol is capable of regulating astrocyte functions, we studied the response of human ONH astrocytes to 3alpha-diol compared with 17beta-hydroxy-17alpha-methyl-estra-4,9,11-trien-3-one (R1881), a synthetic 5alpha-DHT agonist. In ONH astrocytes, both 3alpha-diol and R1881 increased protein levels of androgen receptor (AR) and glial fibrillary acidic protein (GFAP), however, only R1881 also increased the AR mRNA level and astrocyte proliferation. Both R1881 and 3alpha-diol rapidly activate the mitogen-activated protein kinase (MAPK) signaling pathway in ONH astrocytes, as confirmed by phosphorylation of extracellular signal-regulated kinase (ERK). 3Alpha-diol also activates the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway. 3Alpha-diol regulates the increase of AR protein level and the phosphorylation through the PI3K/Akt pathway, whereas R1881 regulates them through the MAPK/ERK pathway. Our findings demonstrate that human ONH astrocytes are androgen target cells and respond to androgens by the rapid activation of cell signaling. The activation of the PI3K/Akt pathway by 3alpha-diol may regulate various properties of astrocytes, including cell motility and survival, and may play a role in the formation and maintenance of the reactive phenotype of ONH astrocytes in glaucoma.

J Steroid Biochem Mol Biol. 2016 Aug;86(2):207-16.

Sex steroid hormone metabolism takes place in human ocular cells.

Coca-Prados M, Ghosh S, Wang Y, Escribano J, Herrala A, Vihko P.

Department of Ophthalmology and Visual Science, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06510, USA.

Steroids are potentially important mediators in the pathophysiology of ocular diseases. In this study, we report on the gene expression in the human eye of a group of enzymes, the 17beta-hydroxysteroid dehydrogenases (17HSDs).

--------------------------

you can block 17B HSD or 3B HSD with fluconazole or ketoconazole.
some times, i suffer intraocular pressure (but normal bp) and i get relief from telmisartan (micardis).

dr frankenstein


   
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MrAnderson
(@mranderson)
Eminent Member
Joined: 5 years ago
Posts: 34
Topic starter  

I will have to re-read this a few times over. This is the reason I come here!
Os, can you tell me what it feels like when you feel intraocular pressure.
also, is there reason to suspect that aas could possibly cause a person who is pre-glaucoma to have glaucoma. I'm trying to weigh out the risks and benefits here.
You think there may be a way to test for this?


   
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oswaldosalcedo
(@oswaldosalcedo)
Estimable Member
Joined: 6 years ago
Posts: 243
 
Posted by: MrAnderson
I will have to re-read this a few times over. This is the reason I come here!
Os, can you tell me what it feels like when you feel intraocular pressure.
also, is there reason to suspect that aas could possibly cause a person who is pre-glaucoma to have glaucoma. I'm trying to weigh out the risks and benefits here.
You think there may be a way to test for this?

but 125 mg it is very little.

blury vision,watery eyes,incapability to focus,tired,
reddish eyes.

dr frankenstein


   
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