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nsaid timing in exercise and bone density  

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jboldman
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22/05/2020 11:53 am  

it is well known that resistance exercise has positive benefits for bone mineral density. this abstract points out that inappropriate use of nsaids can impair that.

jb

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J Bone Miner Res. 2010 Jan 14. [Epub ahead of print]

Timing of ibuprofen use and bone mineral density adaptations to exercise training.
Kohrt WM, Barry DW, Van Pelt RE, Jankowski CM, Wolfe P, Schwartz RS.

Department of Medicine, Division of Geriatric Medicine, University of Colorado Denver.

Prostaglandins (PGs) are essential signaling factors in bone mechanotransduction. In animals, inhibition of the enzyme responsible for PG synthesis (cyclo-oxygenase) by non-steroidal anti-inflammatory drugs (NSAIDs) blocks the bone formation response to loading when administered before, but not immediately after, loading. The aim of this proof-of-concept study was to determine whether the timing of NSAID use influences BMD adaptations to exercise in humans. Healthy, premenopausal women (n = 73) aged 21 to 40 years completed a supervised 9-month weight-bearing exercise training program. They were randomized to take 1) ibuprofen (400 mg) before exercise, placebo after (IBUP/PLAC); 2) placebo before, ibuprofen after (PLAC/IBUP); or 3) placebo before and after (PLAC/PLAC). Relative changes in hip and lumbar spine bone mineral density (BMD) from before to after exercise training were assessed using a Hologic Delphi-W DXA instrument. Because this was the first study to evaluate whether ibuprofen use affects skeletal adaptations to exercise, only women who were compliant to exercise were included in the primary analyses (IBUP/PLAC, n = 17; PLAC/PLAC, n = 23; PLAC/IBUP, n = 14). There was a significant effect of drug treatment, adjusted for baseline BMD, on the BMD response to exercise for regions of the hip (total, P < 0.001; neck, P = 0.026; trochanter, P = 0.040; shaft, P = 0.019), but not the spine (P = 0.242). The largest increases in BMD occurring in the group that took ibuprofen after exercise. Total hip BMD changes averaged -0.2 +/- 1.3%, 0.4 +/- 1.8%, and 2.1 +/- 1.7% in IBUP/PLAC, PLAC/PLAC, and PLAC/IBUP, respectively. This preliminary study suggests that taking NSAIDs after exercise enhances the adaptive response of BMD to exercise, whereas taking NSAIDs before may impair the adaptive response. (c) 2010 American Society for Bone and Mineral Research.


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liftsiron
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22/05/2020 12:16 pm  

WOW!!! Great find.

liftsiron is a fictional character and should be taken as such.


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pSimonkey
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22/05/2020 12:42 pm  

Nice find. Thanks.


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Restless
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22/05/2020 1:06 pm  

If I remember correctly NSAIDS also significantly hinder protein synthesis so that would be enough reason to stay away from them while training.


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rhinofight
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22/05/2020 1:25 pm  

Wouldn't the hinderance of protein synthesis after training be the last thing you want?


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Restless
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22/05/2020 1:47 pm  
Posted by: rhinofight
Wouldn't the hinderance of protein synthesis after training be the last thing you want?

Exactly. It would means less muscle growth. The effect is dose dependent, the guys in the study below found "that the 1.2 g/day maximal over-the-counter dose of ibuprofen is potent enough to blunt the protein synthesis response to resistance exercise. "

http://ajpendo.physiology.org/cgi/content/full/282/3/E55 1" target="_blank" rel="noopener"> http://ajpendo.physiology.org/cgi/c...full/282/3/E551


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rhinofight
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22/05/2020 2:16 pm  

my chiro told me yesterday out of aspirin, ibuprofen, and acetaminophen, the latter had the least hindrance on protein synthesis.


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jboldman
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22/05/2020 2:46 pm  

i have just stopped using them period! except of course my mandatory 81mg aspirin at bedtime.

jb


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Seabiscuit Hogg
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22/05/2020 3:07 pm  

I only take 81 mgs of aspirin too. Does acetaminophen limit protein synthesis at all? It's not an nsaid.

Seabiscuit Hogg is a fictious internet character. It is not recommended that you receive medical advice from fictious internet characters.

SBH :)


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rhinofight
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22/05/2020 3:23 pm  

I was told it does but to a lesser degree than aspirin or ibupfrofen.


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Restless
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22/05/2020 3:52 pm  
Posted by: Seabiscuit Hogg
I only take 81 mgs of aspirin too. Does acetaminophen limit protein synthesis at all? It's not an nsaid.

Apparently it does. From the study above:

"In conclusion, the increased rate of muscle protein synthesis normally seen 24 h after high-intensity eccentric resistance exercise was attenuated by consumption of ibuprofen and acetaminophen at over-the-counter levels. The long-term influence of this acute response after resistance exercise for individuals who chronically consume these (or similar) drugs cannot be determined from this study. However, long-term use of these drugs may inhibit the normal hypertrophic response to resistance training. Future studies on the impact of chronic consumption of over-the-counter doses of these drugs on skeletal muscle are warranted. "


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Seabiscuit Hogg
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22/05/2020 4:17 pm  

Bummer. I have to take it some due to lingering pain from broken bones.don't take it prior to training tho.

Seabiscuit Hogg is a fictious internet character. It is not recommended that you receive medical advice from fictious internet characters.

SBH :)


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Cowgirl
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22/05/2020 5:22 pm  

I rarely take them but have needed them due to a neck injury. This gives me a good reason to stop using them as soon as possible!

Thanks JB


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