pharmaceutical grade dmso: use to rub on injectables?  

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JGUNS
(@jguns)
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25/03/2019 9:00 am  

The new DMSO bottles come with a pump dispensor, so you could actually pre mix everything and just pump. It is a big pump so you could pretty much get everything through it.


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ersatz
(@ersatz)
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25/03/2019 9:33 am  
Posted by: pSimonkey
Thanks heavyweight. Anyone know the purpose of sodium hydroxide?

Sodium hydroxide is a strong base which is used ot adjust the ph of the solution. Carbomer 940(a gelling/thickening agent) requires a ph in the range of 5-7, although for transdermal preps I find the range needs to be 7-7.5. If the ph doesn't fall within this range then when you add the carbomer it mixes only with the water soluble compounds.


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pSimonkey
(@psimonkey)
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25/03/2019 10:21 am  

Thank you ersatz, so what is the optimum ph for a transdermal and why?


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DocJ
 DocJ
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25/03/2019 10:56 am  
Posted by: heavyweight
Test 50mg
carbomer 940
ethyl alcohol 68.9%
isopropol myristate
sodium hydroxide
water

forgive me if i'm being dense, what are the % per compound for that formula? thanks...


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ersatz
(@ersatz)
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25/03/2019 11:40 am  

The optimum ph should be around 7 which makes it fairly neutral. For the carbomer to work, ie thicken the solution into a gel, the ph needs to be in a certain range as previously mentioned.

DocJ: that looks like the ingredients in AndroGel which only had a 10% absorption rate. You can construct better carriers with higher absorption rates closer to 30%.


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JGUNS
(@jguns)
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25/03/2019 12:36 pm  

Where are some of you getting your glycerin from?


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heavyweight
(@heavyweight)
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25/03/2019 1:14 pm  
Posted by: ersatz

DocJ: that looks like the ingredients in AndroGel which only had a 10% absorption rate. You can construct better carriers with higher absorption rates closer to 30%.

It is androgel, I did say I got it from the doctors. That is why I am using it with DMSO

This post was modified 3 weeks ago by Admin

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SJA
 SJA
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25/03/2019 2:06 pm  

Just wanted to revive this thread. Has anyone figured out how much carbomer to use per XX ML solution?


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