ALMOST PRO - or other chemists - help me decipher this abstract plz!

Trying to figure out, with 6-bromoandrostenedione: which form - the alpha or beta -is the most effective as an anti-estrogen / anti-aromatase. Can anyone decipher this. So far...I think the alpha is an estrogen suppressant that occupies the receptor site and beta is a sucide aromatase inhibitor that binds to the aromatase enzyme. Anyone? I've got 50/50 blend of the compound on the way for trials. Synthesis and biochemical properties of 6-bromoandrostenedione derivatives with a 2,2-dimethyl or 2-methyl group as aromatase inhibitors. Numazawa M, Handa W, Yamada K. Tohoku Pharmaceutical University, Sendai, Japan. [email protected] To gain insight into the mechanism for irreversible inactivation of aromatase by 6beta-bromoandrostenedione (1), one of the earliest discovered suicide substrates, in relation to the catalytic function of the enzyme, the 2,2-dimethyl derivative of compound 1, steroid 4, and its 6alpha-isomer 5, as well as 2-methyl-1,4-diene steroid 8 and its 6alpha-bromide 10, were synthesized. All of the steroids inhibited aromatase activity in human placental microsomes with apparent K(i)'s ranging between 10 and 81 nM. The 2,2-dimethyl-6beta- and 6alpha-bromo steroids 4 and 5 were extremely powerful inhibitors (K(i): 14 and 10 nM, respectively), but these two did not cause a time-dependent inactivation of aromatase in the presence of NADPH; in contrast, the 2-methyl-1,4-diene steroids 8 and 10 caused time-dependent inactivation with apparent k(inact) of 0.035 and 0.071 min(-1), respectively, in a suicide manner. These results indicate that the 2,2-dimethyl function of the 6beta-bromide 4 would prevent the inactivation of aromatase caused by inhibitor 1 in a suicide manner, probably through steric activity, whereas the 2-methyl group of steroid 8 did not significantly affect the suicidal inactivation by the parent 1,4-diene steroid, a typical suicide substrate. PMID: 15516742 [PubMed - indexed for MEDLINE]