low dose HCG every 2 weeks?  

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triguy
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24/08/2018 3:33 pm  

when someone does HCG every 2 weeks during a cycle why are the shots taken 2 days in a row? and why is it 2 shots? test levels from hcg last 4-5 days, why the 2nd shot? & why the 2nd day after the 1st? why not wait a couple days to get the surge from the 2nd shot


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ready2explode
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24/08/2018 4:50 pm  

It has been shown that injecting HCG two days in a row doesn't have any different result than injecting the same total amount in a single day. So to answer your question, those that use this practice can save a needle and throw it in one syringe.

Personally, I'm going to shoot hcg EOD during my next cycle. There was a study on here that you can find using my name and jboldman's name (he posted it) that shows the responses of a few different dosages of hcg shot EOD. I threw the data into a scatter plot using excel and added a trend line. Baseline test levels would be acheived using about 305ius EOD. I'm going to give this a try next cycle instead of the standard dosing (on this board anyway) of 500ius 2x a week (most that I know of shoot mon/thurs).

"In any contest between power and patience, bet on patience."
~W.B. Prescott

"Only two things are infinite, the universe and human stupidity, and I'm not sure about the former."
~Albert Einstein


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Black Baccara
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24/08/2018 5:57 pm  
Posted by: ready2explode
It has been shown that injecting HCG two days in a row doesn't have any different result than injecting the same total amount in a single day. So to answer your question, those that use this practice can save a needle and throw it in one syringe.

Personally, I'm going to shoot hcg EOD during my next cycle. There was a study on here that you can find using my name and jboldman's name (he posted it) that shows the responses of a few different dosages of hcg shot EOD. I threw the data into a scatter plot using excel and added a trend line. Baseline test levels would be acheived using about 305ius EOD. I'm going to give this a try next cycle instead of the standard dosing (on this board anyway) of 500ius 2x a week (most that I know of shoot mon/thurs).

could you give me a link plz


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ready2explode
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25/08/2018 5:32 am  

I found the thread, and saw that you also posted this study, BB. I commented on the thread Jb made that is why his name always stuck in my head.

J Clin Endocrinol Metab. 2005 Feb 15; [Epub ahead of print] Related Articles, Links

LOW DOSE HUMAN CHORIONIC GONADOTROPIN MAINTAINS INTRATESTICULAR Testosterone IN NORMAL MEN WITH TESTOSTERONE INDUCED GONADOTROPIN SUPPRESSION.

Coviello AD, Matsumoto AM, Bremner WJ, Herbst KL, Amory JK, Anawalt BD, Sutton PR, Wright WW, Brown TR, Yan X, Zirkin BR, Jarow JP.

Center for Research in Reproduction and Contraception, Geriatric Research Education and Clinical Center, Veteran Affairs Puget Sound Health Care System (AMM), and Department of Medicine, University of Washington School of Medicine (ADC, WJB, JKA, BDA, PLS), Seattle, WA; Department of Medicine, Charles R. Drew University (KLH), Los Angeles, CA; Department of Urology, Johns Hopkins University School of Medicine (XY, JPJ), Baltimore, MD; Division of Reproductive Biology, Department of Biochemistry and Molecular Biology Johns Hopkins University School of Public Health (WWW, TRB, XY, BRZ, JPJ), Baltimore, MD.

In previous studies of testicular biopsy tissue from healthy men, intratesticular testosterone (ITT) has been shown to be much higher than serum testosterone (T), suggesting that high ITT is needed relative to serum T for normal spermatogenesis in men. However, the quantitative relationship between ITT and spermatogenesis is not known. To begin to address this issue experimentally we sought to determine the dose response relationship between human chorionic gonadotropin (HCG) and ITT to determine the minimum dose needed to maintain ITT in the normal range. Twenty-nine men with normal reproductive physiology were randomized to receive 200 mg T enanthate (TE) weekly in combination with either saline placebo or hCG 125 IU, 250 IU, or 500 IU every other day for 3 weeks. ITT was assessed in testicular fluid obtained by percutaneous fine needle aspiration at baseline and the end of treatment. Baseline serum T (14.1 nmol/L) was 1.2% of ITT (1174 nmol/L). LH and FSH were profoundly suppressed to 5% and 3% of baseline respectively, and ITT was suppressed by 94% (1234 nmol/L to 72 nmol/L) in the TE/placebo group. ITT increased linearly with increasing hCG dose (P < 0.001). Post-treatment ITT was 25% less than baseline in the 125 IU hCG group, 7% less than baseline in the 250 IU hCG group, and 26% greater than baseline in the 500 IU hCG group. These results demonstrate that relatively low dose hCG maintains ITT within the normal range in healthy men with gonadotropin suppression. Extensions of this study will allow determination of the ITT concentration threshold required to maintain spermatogenesis in man.

"In any contest between power and patience, bet on patience."
~W.B. Prescott

"Only two things are infinite, the universe and human stupidity, and I'm not sure about the former."
~Albert Einstein


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Zircon
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25/08/2018 6:31 am  

So for a 10 week T E cycle at 500mg per week, do you suggest HCG? If so, when? Right from the start of the cycle? Last 3-4 weeks only?

Thanks


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liftsiron
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25/08/2018 7:13 am  
Posted by: Zircon
So for a 10 week T E cycle at 500mg per week, do you suggest HCG? If so, when? Right from the start of the cycle? Last 3-4 weeks only?

Thanks

Need for hcg is such an individual thing. I never use it anymore because I don't experience testical shrinkege. I think that you would be safe if you started in the 3rd week of your cycle and injected 500ius twice per week. Also it's wise to use 10-20 mgs nolva concurrent with hcg use.

liftsiron is a fictional character and should be taken as such.


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triguy
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25/08/2018 7:55 am  

......is it true HCG is acts as a LH analog?

......works at the testes?

....works at the pituitary, stimulating GNRH then LH to stimulate test?


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HitMeBack
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25/08/2018 8:46 am  
Posted by: liftsiron
Need for hcg is such an individual thing. I never use it anymore because I don't experience testical shrinkege. I think that you would be safe if you started in the 3rd week of your cycle and injected 500ius twice per week. Also it's wise to use 10-20 mgs nolva concurrent with hcg use.

I'd imagine this would largely depend on your AAS of choice, as some AAS can almost completely shut down ITT within as little as 24 hours. The testicular shrinkage is a much later sign of ITT suppression. Why not start hCG right from the beginning of your cycle so that you can avoid any ITT suppression?


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jboldman
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25/08/2018 9:48 am  

as lifts said. it is largely an individual matter whether or not you experience Testicular shrinkage. Frankly i used for years and never experienced it. Nowadays i do 500mcg of hcg once a week.

jb


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HitMeBack
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25/08/2018 10:37 am  

But why anyone wouldn't want to avoid ITT suppression in the first place is beyond me. Subjective testicular shrinkage is a much later stage of ITT suppression


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Zircon
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25/08/2018 11:24 am  

ok how does this sound. I'm running an 8 weeker T enan 500mg. then 3 weeks prop 125mg eod, to finish off. In the last 5 weeks of the cycle run 1000 iu per week hcg (divided into 2 shots fo 500).

Then 4 weeks pct. Is this a reasonabel thing to do? I will meausre my nut size before cycle (lol), and if necessary take hcg. If not, just leave it out?

Thanks


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