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Peptides (HGH, HCG, Insulin)
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Topic starter
29/03/2020 7:59 pm
Clin Nutr. 2009 Sep 19. [Epub ahead of print] Links
Growth hormone and protein metabolism.Moller N, Vendelbo MH, Kampmann U, Christensen B, Madsen M, Norrelund H, Jorgensen JO.
Medical Department M (Endocrinology & Diabetes), Aarhus University Hospital, DK 8000 Aarhus, Denmark and Clinical Institute, Aarhus University, DK 8000 Aarhus, Denmark.
Growth hormone (GH) and intracellular STAT 5 signalling represents a very old regulatory system and, whereas insulin dominates periprandially, GH may be viewed as the primary anabolic hormone during stress and fasting. GH exerts metabolic effects both directly and through stimulation of IGF-I, insulin, and free fatty acids (FFA). When well nourished the GH-induced stimulation of IGF-I and insulin is important for tissue anabolism whereas during fasting and other catabolic states GH predominantly stimulates the release and oxidation of FFA which leads to decreased glucose and protein oxidation and preservation of LBM. The most prominent metabolic effect of GH is a marked increase in lipolysis and FFA levels. In the periprandial and postabsorptive states the effects of GH on protein metabolism are modest and include increased protein synthesis and decreased breakdown at the whole body level and in muscle together with decreased amino acid degradation/oxidation and decreased hepatic urea formation. During fasting and stress the effects of GH on protein metabolism become more pronounced; lack of GH during fasting increases protein loss and urea production rates by approximately 50% with a similar increase in muscle protein breakdown. The importance of GH is further substantiated by the observations that adult patients with GH-deficiency are obese and have reduced LBM, and impaired physical performance and acromegaly is characterised by increased LBM and decreased fat mass.
29/03/2020 8:18 pm
This just helps verify why GH is so kick ass. It also explains my lack of cravings for carbs whilest on CJC. Put another notch in the GH belt. It also explains why I am getting bigger and leaner at the same time.
i was the 1997 International Spelling Bee Winnur
29/03/2020 8:34 pm
so, if i read it correctly
GH alone = fat loss
GH + slin = growth
29/03/2020 9:02 pm
So, is GH a waste without slin then?
Disclaimer:
Information that Tazmaniac presents is totally fictitious in nature and is presented for role playing purposes only. The opinions presented do not encourage the use of illegal substances nor take the place of professional medical advice.
Death gotta be easy, cause life is hard...it'll leave you physically, mentally, and emotionally scarred~50 Cent
Topic starter
29/03/2020 9:33 pm
well, in order, gh + slin = anabolism but the slin mentioned was that slin induced by gh in a well nourished state (eg gh plus food). in afasting state, you see lipolysis (fat burning) and protein sparing ( prevention of muscle loss) this article clarifies some of the actions that we have been talking about. also backs up what i have been experiencing about gh and dieting.
jb
29/03/2020 9:52 pm
Interesting JB. I've only used GH for rehab purposes at a low dose and it was tremendous. I've seen mixed things back and forth about with/without slin for fat burning/anabolism.
The reason why this is of interest however is that I'm following the Rapid Fat Loss Handbook that Lyle Mcdonald wrote (just started it a week ago). This diet focuses on fat burning and protein sparing. Though I'm only a week through it, I could definitely tell a difference with my body. This diet is strict and requires you to do about 1000 calories a day but I was thinking if using GH, I wonder how much effective this diet could be for fat loss.
Any thoughts? GH or GH/Slin?
Disclaimer:
Information that Tazmaniac presents is totally fictitious in nature and is presented for role playing purposes only. The opinions presented do not encourage the use of illegal substances nor take the place of professional medical advice.
Death gotta be easy, cause life is hard...it'll leave you physically, mentally, and emotionally scarred~50 Cent
29/03/2020 10:09 pm
WHY USE SLIN!!!!!!! I am sure JB will back me on this one but I dont feel slin is neccesariy for any of us unless we plan on competing in the BB community or are some kind of athlete that depends on his/her sport for income. It can be soo dangerous. Unlike anything else we ever take Insulin has the smallest room for error with the greatest consequence which is death. Thats just my opinion as I want to keep all the people on the board safe. I feel diet, anabolics, gh and other PEDS or more then enough for 95% of us.
i was the 1997 International Spelling Bee Winnur
29/03/2020 10:39 pm
WHY USE SLIN!!!!!!! I am sure JB will back me on this one but I dont feel slin is neccesariy for any of us unless we plan on competing in the BB community or are some kind of athlete that depends on his/her sport for income. It can be soo dangerous. Unlike anything else we ever take Insulin has the smallest room for error with the greatest consequence which is death. Thats just my opinion as I want to keep all the people on the board safe. I feel diet, anabolics, gh and other PEDS or more then enough for 95% of us.
The safety aspect of using slin is why I haven't used it. I really don't know if it's necessary. Depending on who you talk with, some guys think it's absolutely necessary while others don't.
Disclaimer:
Information that Tazmaniac presents is totally fictitious in nature and is presented for role playing purposes only. The opinions presented do not encourage the use of illegal substances nor take the place of professional medical advice.
Death gotta be easy, cause life is hard...it'll leave you physically, mentally, and emotionally scarred~50 Cent
29/03/2020 10:55 pm
The safety aspect of using slin is why I haven't used it. I really don't know if it's necessary. Depending on who you talk with, some guys think it's absolutely necessary while others don't.
Yea, well the people who say you absolutely have to use it are absolutely ignorant and are probably the 240lb online beast who are in actuality 16 only weighing a buck 20
i was the 1997 International Spelling Bee Winnur
29/03/2020 11:16 pm
WHY USE SLIN!!!!!!! I am sure JB will back me on this one but I dont feel slin is neccesariy for any of us unless we plan on competing in the BB community or are some kind of athlete that depends on his/her sport for income. It can be soo dangerous. Unlike anything else we ever take Insulin has the smallest room for error with the greatest consequence which is death. Thats just my opinion as I want to keep all the people on the board safe. I feel diet, anabolics, gh and other PEDS or more then enough for 95% of us.
i definately disagree with that viewpoint!
imo slin is WAY safer than GH.
with slin, all you need to do is follow procedure, and have a buddy watching you for its active life, and some glucose tabs close by.
if you do that, you're VERY safe. oh, and you need to keep the usage length within reason. 4 weeks of usage isnt going to do anything to a healthy person, but im sure that prolonged usage can cause problems.
if those 2 conditions are met, i cant see how any1 can get into any trouble at all, ever(getting fat doesnt count here)
with GH though, you have to remember that every cancer cell in your body is having a party every time you use. other than that, you can enlarge internal organs, cause acromegaly etc.
im not against GH at all, but in the long run i definately think intelligent slin usage is safer.
edit: also, its is exactly because of theese views of mine that i think that GH should ALWAYS be used with slin. imo GH is too risky and expensive to be used just for fat loss Last edited by nEEd4wEEd on 09-26-2009 at 03:19 AM
29/03/2020 11:37 pm
GH has never been shown to cause cancer.
GH has never killed anyone
GH has little to no known risk
Gh cant kill you at any dose. Slin can at any dose
You cant compare my friend
Enlarged organs and acromegaly is a sure sign of ABUSE, not use
And no one knows for sure about the enlarged organs as likely as it may be I dont know if their is even a correlation to organs and gh
You didnt present any facts in your argument.
i was the 1997 International Spelling Bee Winnur
30/03/2020 12:01 am
WHY USE SLIN!!!!!!! I am sure JB will back me on this one but I dont feel slin is neccesariy for any of us unless we plan on competing in the BB community or are some kind of athlete that depends on his/her sport for income. It can be soo dangerous. Unlike anything else we ever take Insulin has the smallest room for error with the greatest consequence which is death. Thats just my opinion as I want to keep all the people on the board safe. I feel diet, anabolics, gh and other PEDS or more then enough for 95% of us.
Not to take this topic so far off from its base, but I also disagree with this. Most people that are so against the use of Slin are usually the ones who have never used it.
As long as you don't go into it blindly, it really is nowhere near as bad as some people make it out to be.
Nice article jboldman.
Topic starter
30/03/2020 12:20 am
ok guys, as usual, the truth is down that middle road. slin has been used successfully and safely for many years by many people. it really depends on your goals. i have personally never used it and so try not to come down one way or the other. we all can agree that it requires a great deal of caution on the part of the user and certainly can result in some serious consequences. those that have used it swear by it and i have no doubt that it lives up to its reputation as "natures greatest anabolic". it also requires accurate timing and careful monitoring to maximize the effects and minimize the risks, something that i personally have not felt the need for.
gh, while in some cases can lead to internal organ growth and insulin resistance is also an effective fat burner and protein sparer something that is very useful for dieting. while i agree that it is expensive and anyone looking for just anabolism is better off spending their money on test, gh has its uses. anecdotally i have found that dieting while using gh and test is the most effective combination that i have used. i have been on a diet/growth revolving cycle for many years and so far the best combo for ME has be test/gh/diet/cardio. it appears that if you are lookin g for anabolism just add food to the combination and the commitant spike in igf-1 and insulin will do the rest. the recent popularity of cjc-1295 and other peptides may relace gh, we will have to wait and see. exo insulin is best left for another thread which i would welcome.
jb
30/03/2020 12:48 am
Im not coming down on people who use it or knocking them. I am just very concerned about my fellow CEM members well being. For most of us our goals can be accomplished without the use of slin. I have no doubt it works and works well. I just think its a risk most need not take. I feel(and again Ive never used slin so I could be dead wrong) our goals could be accomplished with tweaking our anabolics or diets therefore bypassing the risk associated with slin alltogether.
i was the 1997 International Spelling Bee Winnur
30/03/2020 1:17 am
So, is GH a waste without slin then?
Absolutely not. This is the first time I have ever taking a real gh booster and I have to say that gh has a remarkable synergy with test. I am getting big quick while I am steadily loosing weight. i will say I carry more water weight then I am use to b/c of the gh
i was the 1997 International Spelling Bee Winnur