Blocking progesterone.  

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gtrack
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03/06/2019 7:29 am  

Is there any effective substance to block progesterone available ?
I'm far from a pregnant woman willing to abort and i'm very prone to gyno from deca and tren which sadly prevents me from using them.
It's about progesterone only effects as i've tried using them with both AIs and SERMs and still got the gyno.

Does letro have any PR antagonist effects ?winstrol ? Bromo or cabergoline ? Is there any documented merit to using any of those to block progesterone ?
Any help welcome.


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ready2explode
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03/06/2019 7:54 am  

Try using tren without an aromatizing agent. I'm extremely prone to gyno, but can run a gram of tren enan solo without a problem. I keep some test susp or prop on hand if my sex drive drops too far. 50mgs of prop per week is plenty. 50mgs of the susp is good also, but it needs to be split into 2 doses.

"In any contest between power and patience, bet on patience."
~W.B. Prescott

"Only two things are infinite, the universe and human stupidity, and I'm not sure about the former."
~Albert Einstein


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jboldman
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03/06/2019 8:22 am  

that is what i would suggest as well.

jb


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gtrack
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03/06/2019 8:50 am  

Last cycle was tren enan 400mg/ew,50mg stanoz ed,30mg var ed ,cabergoline ,raloxifene and exemestane and still had gyno aggrevated.So,it seems i'm helpless...


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DocJ
 DocJ
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03/06/2019 9:19 am  

Re: Re: Blocking progesterone.

Posted by: gtrack
Last cycle was tren enan 400mg/ew,50mg stanoz ed,30mg var ed ,cabergoline ,raloxifene and exemestane and still had gyno aggrevated.So,it seems i'm helpless...

Wow! You are sensitive...sorry bro.


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Big Cat
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03/06/2019 9:41 am  

There is still little evidence for the involvement of progesterone in gyno. With deca they studied the effect of progesterone blocking on estrogenic effects, and it had no effect whatsoever. So the progesterone may not be causing it.

Definitely avoid the deca, since it likely causes estrogenic effects via the AR, meaning you can use all the anti-e's in the world, they won't help with deca.

If you are still set on trying anti-progestins, take into account that most of them are also AR blockers.

Good things come to those who weight.

The Big Cat is a researcher and theoreticist. His advice must never be taken in the stead of proper advice from a medical professional, it is entirely intended for research purposes.


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liftsiron
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03/06/2019 9:59 am  

B-6 at 200mgs twice per day has some benefit in protecting against progestrone related sides.

liftsiron is a fictional character and should be taken as such.


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gtrack
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03/06/2019 10:17 am  
Posted by: Big Cat
There is still little evidence for the involvement of progesterone in gyno. With deca they studied the effect of progesterone blocking on estrogenic effects, and it had no effect whatsoever. So the progesterone may not be causing it.

Definitely avoid the deca, since it likely causes estrogenic effects via the AR, meaning you can use all the anti-e's in the world, they won't help with deca.

If you are still set on trying anti-progestins, take into account that most of them are also AR blockers.

Originally the problem did start with deca,but i have 3 years to use it and just use tren from the PR agonist steroids.And when on cycle things go worse no matter what i do and things get a little better when off.

Which antiprogestins are you refering to ? Would they bind so strongly so as to even dislocate tren ?
I could probably use anything right now,especially when i'm off.

Thanks for the b6 recommendation,i'll try that for a couple of months and see what happens.What about bromocryptine ?


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Big Cat
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03/06/2019 10:42 am  

well, Spironolactone for instance, is a PR blocker.

Good things come to those who weight.

The Big Cat is a researcher and theoreticist. His advice must never be taken in the stead of proper advice from a medical professional, it is entirely intended for research purposes.


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jboldman
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03/06/2019 11:08 am  

but also a diuretic and anti-androgen. use with care.

jb


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guijr
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03/06/2019 11:30 am  
Posted by: jboldman
but also a diuretic and anti-androgen. use with care.

jb

What would be a good anti-androgen?

"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.


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gtrack
(@gtrack)
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03/06/2019 11:58 am  

I've been searching the web for a couple of days looking for possible options and indeed i have also found about Spironolactone.
I also found cortisol and cortisone can block progesterone and trilostane ,which blocks both progesterone and cortisol but can't find it anywhere.
What dosages of Spironolactone would be effective for PR blocking and for how long should i stay on it ?

guijr,other substances that could work as antiandrogens would be dht conversion inhibitors (like finasteride and dutestaride) and steroids like cyproterone.

Thanks for your replies.


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guijr
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03/06/2019 12:17 pm  
Posted by: gtrack
guijr,other substances that could work as antiandrogens would be dht conversion inhibitors (like finasteride and dutestaride) and steroids like cyproterone.


Thanks for the info, but I'm afraid that these substances (finasteride and dutestaride) and are related with libido problems. Never heard of cyproterone.

This post was modified 4 months ago by Admin

"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.


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jboldman
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03/06/2019 12:36 pm  

why are we looking for anti-androgens now?

jb


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guijr
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03/06/2019 1:06 pm  

You mean, me?

"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.


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