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Blocking progesterone.

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jboldman
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yup

jb


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gtrack
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I suppose we could open a different thread on antiandrogens,this would be best.
One last sentence about them : with antiandrogens lower libido is a given.You actually try to block the AR.

Anyone have more info about trilostane ? It's used in dogs' cushing syndrome and found some studies on women with breast cancer.It's very strange that there's no therapy for combating too much progesterone in women.I'd think this could be a problem for a number of women worth having a substance for.


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guijr
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Posted by: jboldman
yup

jb

Not looking for personal (cycling) purposes, just for educational ones. Would not be smart trying to block DHT for a guy who just started TRT.

"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.


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Big Cat
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Posted by: jboldman
but also a diuretic and anti-androgen. use with care.

jb

That's what I said, all PR blockers I know of are also mild AR blockers.

With spiro I wouldn't worry too much about the diuretic effect. In most athletes Caffeine is a stronger diuretic, and not worth using for that purpose given its AR-blocking effect.

Good things come to those who weight.

The Big Cat is a researcher and theoreticist. His advice must never be taken in the stead of proper advice from a medical professional, it is entirely intended for research purposes.


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Big Cat
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Posted by: guijr
Thanks for the info, but I'm afraid that these substances (finasteride and dutestaride) and are related with libido problems. Never heard of cyproterone.

Cyproterone acetate and flutamide (or 4-OH-flutamide) are the two most commonly used AR blockers. And like the others said, AR-blockers are likely to have the same effect on libido.

Good things come to those who weight.

The Big Cat is a researcher and theoreticist. His advice must never be taken in the stead of proper advice from a medical professional, it is entirely intended for research purposes.


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Big Cat
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quote:


Anyone have more info about trilostane ? It's used in dogs' cushing syndrome and found some studies on women with breast cancer.It's very strange that there's no therapy for combating too much progesterone in women.I'd think this could be a problem for a number of women worth having a substance for.

Arzneimittelforschung. 1983;33(5):754-6.

The inhibiting effect of trilostane on Testosterone synthesis. Hormonal and morphologic alterations induced by subchronic trilostane treatment in rats and healthy volunteers.

Jungmann E, Althoff PH, Balzer-Kuna S, Magnet W, Rottmann-Kuhnke U, Sprey R, Schwedes U, Usadel KH, Schoffling K.

(2 alpha, 4 alpha, 5 alpha, 17 beta)-4, 5-[Epoxy-17-hydroxy-3-oxo-androstane-2-carbonitrile (Trilostane, Win 24450) is a new, orally active, competitive inhibitor of 3 beta-hydroxysteroid dehydrogenase currently being introduced into therapy of Cushing's disease and primary aldosteronism and being investigated in the treatment of low-renin essential hypertension. In adult male rats and in healthy, young, male volunteers the effect of trilostane on testosterone production was studied. Rats were treated with trilostane 150 mg or 300 mg/kg/d for 7 or 14 days. Testosterone in serum was measured by radioimmunoassay, testes were weighed and Leydig cell nuclear volume determined. In healthy volunteers, dehydroepiandrosterone sulphate (DHEAS) and responses of luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone to luteinizing hormone releasing hormone (LHRH) stimulation were measured by radioimmunoassay before and during trilostane treatment (240 mg/d). In rats, trilostane treatment decreases testosterone and increases Leydig cell nuclear volumes without affecting testicular weight. In volunteers, basal testosterone is not changed during trilostane treatment but testosterone response to LHRH is impaired. DHEAS increases. LH or FSH levels are not altered. It is concluded that trilostane treatment may decrease testosterone synthesis.

Good things come to those who weight.

The Big Cat is a researcher and theoreticist. His advice must never be taken in the stead of proper advice from a medical professional, it is entirely intended for research purposes.


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guijr
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Posted by: Big Cat
Cyproterone acetate and flutamide (or 4-OH-flutamide) are the two most commonly used AR blockers. And like the others said, AR-blockers are likely to have the same effect on libido.

Thanks for the info.

"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.


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gtrack
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Posted by: Big Cat
Arzneimittelforschung. 1983;33(5):754-6.

The inhibiting effect of trilostane on testosterone synthesis. Hormonal and morphologic alterations induced by subchronic trilostane treatment in rats and healthy volunteers.

Jungmann E, Althoff PH, Balzer-Kuna S, Magnet W, Rottmann-Kuhnke U, Sprey R, Schwedes U, Usadel KH, Schoffling K.

(2 alpha, 4 alpha, 5 alpha, 17 beta)-4, 5-[Epoxy-17-hydroxy-3-oxo-androstane-2-carbonitrile (Trilostane, Win 24450) is a new, orally active, competitive inhibitor of 3 beta-hydroxysteroid dehydrogenase currently being introduced into therapy of Cushing's disease and primary aldosteronism and being investigated in the treatment of low-renin essential hypertension. In adult male rats and in healthy, young, male volunteers the effect of trilostane on testosterone production was studied. Rats were treated with trilostane 150 mg or 300 mg/kg/d for 7 or 14 days. Testosterone in serum was measured by radioimmunoassay, testes were weighed and Leydig cell nuclear volume determined. In healthy volunteers, dehydroepiandrosterone sulphate (DHEAS) and responses of luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone to luteinizing hormone releasing hormone (LHRH) stimulation were measured by radioimmunoassay before and during trilostane treatment (240 mg/d). In rats, trilostane treatment decreases testosterone and increases Leydig cell nuclear volumes without affecting testicular weight. In volunteers, basal testosterone is not changed during trilostane treatment but testosterone response to LHRH is impaired. DHEAS increases. LH or FSH levels are not altered. It is concluded that trilostane treatment may decrease testosterone synthesis.

I guess this effect would go unnoticed in the presence of externally administered androgens.
Trilostane seems the best bet (besides ru486) but for the time being is very hard to find and seems to reduce overall steroidogenesis,kinda like aminoglutethimide ?


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Big Cat
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Posted by: gtrack
I guess this effect would go unnoticed in the presence of externally administered androgens.
Trilostane seems the best bet (besides ru486) but for the time being is very hard to find and seems to reduce overall steroidogenesis,kinda like aminoglutethimide ?

I think it would likely be a better bet than ru486, which seems to act like a temporal and spatial SARM and may therefore have androgen receptor blocking properties that interfere with your androgens. That shouldn't be a problem with trilostane that just blocks 3bHSD. Of course, what exactly is the point of using a cort blocker on-cycle ? Most AAS block glucocorticoid effects in more ways than one. Cort-blockers only really pay off during PCT, and that's when trilostane is most advised against since it will interfere with recovery, more than it will help.

Good things come to those who weight.

The Big Cat is a researcher and theoreticist. His advice must never be taken in the stead of proper advice from a medical professional, it is entirely intended for research purposes.


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oswaldosalcedo
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i have used aldactone no problems at all.
for libido problems (from Dutasteride or finasteride) just use mesterolone 100 mg ed.
PR antagonist mifrepristone.

dr frankenstein


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gtrack
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I have decided to give mifepristone a try.
What would be a safe dosage for using it for about 3 weeks ?

I understand it's a steroid ,but i don't know whether it's methylated or not or the degree of toxicity it could cause.

I'd appreciate any help.


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oswaldosalcedo
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Posted by: gtrack
I have decided to give mifepristone a try.
What would be a safe dosage for using it for about 3 weeks ?

I understand it's a steroid ,but i don't know whether it's methylated or not or the degree of toxicity it could cause.

I'd appreciate any help.

dear gtrack, I recommend you
onapristone (PR Blocker), does not bind to the androgen receptor and have no antiandrogenic activity.

use 10 mg ed. Last edited by oswaldosalcedo on 02-21-2007 at 07:46 PM

dr frankenstein


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gtrack
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onapristone is impossible for me to find.
Mifepristone also is ver hard to get.
What would be a safe dose for mifepristone ?


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oswaldosalcedo
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Posted by: gtrack
onapristone is impossible for me to find.
Mifepristone also is ver hard to get.
What would be a safe dose for mifepristone ?

50 mg ed.

dr frankenstein


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oswaldosalcedo
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.

dr frankenstein


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