Lets start a discussion on neural effects of steroids

Tren...the odd one out Ok, I can't believe I completely missed this. NMDA receptors, otherwise known as the "go" receptor. GABA being is polar opposite the "stop" receptor....

quote:

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Effects of an anabolic-androgenic steroid on the regulation of the NMDA receptor NR1, NR2A and NR2B subunit mRNAs in brain regions of the male rat

Pierre Le Grevès*, Wan Huang, Pia Johansson, Madeleine Thörnwall, Qin Zhou and Fred Nyberg

Department of Pharmaceutical Biosciences, Division of Biological Research on Drug Dependence, Uppsala University, Uppsala, Sweden

Received 31 January 1997; revised 31 March 1997; accepted 31 March 1997. Available online 3 July 1997.

The implication of downregulating NMDA suggests an effect in the reward system of the brain. For example what makes alcohol addicting is that it shuts down NMDA receptors, and activates GABA receptors......Through the shut down of NMDA the brain counteracts this by producing more NMDA receptors, thereby increasing the need for more alcohol(tolerance).....also burning out GABA in reverse.

There is a study combining high doses of deca with cocaine and it increased the addictive qualities of cocaine. The concept was based on the data that showed high levels of Deca caused a downregulation of mRNA for subunit receptor NR1.

Now I thought Tren might increase the levels of NE systemically... what if this is not the case directly. Hypothetically, what if tren really crunches the cortisol response, and then at the same time increase activation of NMDA receptors(increased anxiety)....Would it be possible that the physical stress(fight or flight) hormone response is still occuring, just sans cortisol. And, if this is the case, could NE/E sans cortisol cause an increased level of fat loss?

Technically its not sans cortisol but with moins cortisol, so yes, definitely.

Big Cat, I know this is a little off topic, but if you wanted to lower the activity of NMDA receptors(from excess stimulation) how would you do it?

There are a number of NMDA blockers like Dizocilpine. But I generally don't try to mess with that purposefully.

Re: thanks for that journal monkey

Posted by: BeLargeMini

They found that maintainance of intelligence was optimal in those that continually challenged their minds.

Really pretty old news though, those that keep using thier bodypart or mind, trigger the need to keep it healthy. We have seen studies on how many numbers an elderly person can remember and we know already that those who do best on these tests, are those that keep the mind active.

BTW, Ginkgo Biloba is great, one of the few legal supplements that really do work for me, I use 4x standard dose usually.

Or like tests where people imagine themselves performing something, like shooting hoops. They usually improve thier game "99%" as well as those who actually perform the task, while those who do nothing and think nothing, do not improve. So those that use thier mind, can improve and maintain function many times over.

Re: stumbled across this study on Nandrolone

Posted by: BeLargeMini

High serotonin:
shyness, obsessive compulsions, fearfulness, lack of self confidence, decreased aggression

low serotonin:
depression, suicide, impulsive aggression, alcoholism (which first drink would raise it, subsequent would cause it to go down even further - hence the increased propensity for violence), sexual deviance, explosive rage

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Wow, I always thought more serotonin was better, doh.

what about this ?

Posted by: Big Cat

There are a number of NMDA blockers like Dizocilpine. But I generally don't try to mess with that purposefully.

without messing with NMDA blockers, is there a natural antagonist to glutamate? The tren I went on might have amped up the NMDA receptors. I am experiencing increased sensitivity to touch and sound, as well as headaches around the temporal lobes....Probably it will die down as I move further from the cycle....I like tren, and want to avoid this side effect next time...

Has anyone done any research on Allopregnanolone? What method of delivery should be used and what doses?

http://forum.avantlabs.com/?act=ST&...t=0#entry105272

is alpha keto glutarate a glutamate receptor agonist?

Trends Neurosci. 2006 May;29(5):241-9.

Is brain estradiol a hormone or a neurotransmitter?

Balthazart J, Ball GF.

Center for Cellular and Molecular Neurobiology, University of Liege, B-4000 Liege, Belgium.

Mounting evidence indicates that, besides their well-known hormonal mode of action at the genetic level, estrogens such as 17beta-estradiol also influence brain function by direct effects on neuronal membranes. Experimentally induced rapid changes in estradiol bioavailability in the brain have been shown to alter the expression of male sexual behavior significantly within minutes--probably too quickly to be accounted for by conventional genetic mechanisms. In parallel, recent studies indicate that aromatase, the enzyme that converts Testosterone to estradiol in the brain, is expressed in presynaptic terminals and modulated within minutes by Ca(2+)-dependent phosphorylation. In this article, we develop the hypothesis that brain estrogens display many, if not all, functional characteristics of neuromodulators or even neurotransmitters.

"In the past, scientists have always assumed that the action of estrogens on brain function required at least a few hours or days to produce detectable results," Ball said. "For this reason, relatively little attention was paid to responses that might occur more rapidly. The recent demonstration that estrogen production and action can change dramatically within minutes will change our thinking about when we should consider estrogen to be important in regulating behavior and physiology."