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strength to help muscular distrophy


organdoner
(@organdoner)
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Topic starter  

it runs in the family so i'm wondering what i can suggest to a family member who is feeling the effects of weekness in the legs big time. i know they won't inject. i could give my two cents but i love the answers i get here. money is no object. just a little more strength to help with balance if that makes sense. thanks.


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Nytol2
(@nytol2)
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Are they male or female?

Creatine could be a place to start.

Do they do any sort of strength training? I dont know a great deal about the illness, but if they can make the muscles stronger, then surely it will delay dibilitatating weakness?


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organdoner
(@organdoner)
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Topic starter  

it's a male and in the early stages. mostly just losing his balance which sometimes comming close to falling. like i said it runs in the family. to work the muscles just makes them weaker. i'm just talking about maybe an oral to give a little strength.


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guijr
(@guijr)
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I woud give him strength and cardio training along with some stretching.

"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.


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Nytol2
(@nytol2)
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Posted by: organdoner
it's a male and in the early stages. mostly just losing his balance which sometimes comming close to falling. like i said it runs in the family. to work the muscles just makes them weaker. i'm just talking about maybe an oral to give a little strength.

This is a long term thing and using orals is only suitable short term, if they would actually help at all.

I would look into creatine, there may have even been studies done on it.


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gtrack
(@gtrack)
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If injectables are out of the question,then one oral anabolic could be helpful.
Don't forget,the therapeutic dosages can be as low as 5mg/ed which won't create any significant liver damage or lipid increase.So,var,Dbol or winstrol could be good choices here.


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guijr
(@guijr)
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Along with exercise training creatine and even glutamine could be helpful.

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Matsumura T, Yokoe M, Nakamori M, Hattori N, Saito T, Nozaki S, Fujimura H, Shinno S. A clinical trial of creatine monohydrate in muscular dystrophy patients. Rinsho Shinkeigaku. 2004;44(10):661-6.

ABSTRACT

To investigate the effects of creatine monohydrate on muscle performance and cognitive functions in muscular dystrophy patients, we made an open trial. Twenty-nine individuals, including 14 myotonic dystrophy (DM), seven facioscapurohumeral muscular dystrophy (FSHD), two limb-girdle muscular dystrophy and six healthy volunteers, were enrolled in this study and 27 participants completed it. All participants took creatine 20g/day for an initial week and 5g/day for successive eight weeks. Somatotonic measurements, global subjective assessment, muscle performance, cardiopulmonary function, cognitive function, laboratory studies and magnetic resonance spectroscopy (MRS) were evaluated at both pre and post examination. Subjective improvements were reported from twelve individuals. Contrary adverse effects were also complained from ten individuals, although all these problems were not serious. Quantitative muscle power was slightly but significantly increased in the patients and the number of the patients who failed to complete cycle ergometer test was decreased. Phosphocreatine concentrations of left calf muscle were not different between pre and post trial examination. No obvious changes were detected in cardiopulmonary assessment, cognitive function and laboratory date. Creatine has certain expectance for muscular dystrophy patients in motor performance. The effect may be achieved not only by increase of energy buffer, because clinical improvements were observed in our study nevertheless no increase was detected in phosphocreatine concentration. The usage of creatine should be managed under medical monitoring since ideal protocol has not yet been established and adverse effects can not be ignored.

===========================

Pearlman JP, Fielding RA. Creatine monohydrate as a therapeutic aid in muscular dystrophy. Nutr Rev. 2006;64(2 Pt 1):80-8.

ABSTRACT

In recent years, dietary supplementation with creatine has been shown to enhance neuromuscular function in several diseases. Recent studies have suggested that creatine can be beneficial in patients with muscular dystrophy and other mitochondrial cytopathies, and may attenuate sarcopenia and facilitate rehabilitation of disuse atrophy. Though the mechanisms are still unknown, creatine has been shown to decrease cytoplasmic Ca2+ levels and increase intramuscular and cerebral phosphocreatine stores, providing potential musculoskeletal and neuroprotective effects.

===========================

Escolar DM, Buyse G, Henricson E, Leshner R, Florence J, Mayhew J, Tesi-Rocha C, Gorni K, Pasquali L, Patel KM, McCarter R, Huang J, Mayhew T, Bertorini T, Carlo J, Connolly AM, Clemens PR, Goemans N, Iannaccone ST, Igarashi M, Nevo Y, Pestronk A, Subramony SH, Vedanarayanan VV, Wessel H; CINRG Group. CINRG randomized controlled trial of creatine and glutamine in Duchenne muscular dystrophy. Ann Neurol. 2005;58(1):151-5.

ABSTRACT

We tested the efficacy and safety of glutamine (0.6 gm/kg/day) and creatine (5 gm/day) in 50 ambulant boys with Duchenne muscular dystrophy in a 6-month, double-blind, placebo-controlled clinical trial. Drug efficacy was tested by measuring muscle strength manually (34 muscle groups) and quantitatively (10 muscle groups). Timed functional tests, functional parameters, and pulmonary function tests were secondary outcome measures. Although there was no statistically significant effect of either therapy based on manual and quantitative measurements of muscle strength, a disease-modifying effect of creatine in older Duchenne muscular dystrophy and creatine and glutamine in younger Duchenne muscular dystrophy cannot be excluded. Creatine and glutamine were well tolerated.

"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.


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jboldman
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In duchenne or becker's MD, oxandrolone has been shown to improve protein anabolism. this was published last month. I would be careful to suggest it in the other forms of MD.

jb

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Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E530-9. Epub 2005 Nov 1. Related Articles, Links

Oxandrolone enhances skeletal muscle myosin synthesis and alters global gene expression profile in Duchenne muscular dystrophy.


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organdoner
(@organdoner)
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Topic starter  

cool. see i thought var, dbol or winny would be good too. i just know whenn i come here i'll get the best answers. weight training or cardio will not help with this disease. the muscles just waste away and get weaker. the time you have to maintain the strength you have decreases. i just want him to try just to see if it helps some. the studies with creatine, b12 etc are just that, studies. i work in a cancer center that does studies all the time with various experiments and a scientist i trust says most studies are just for documentation purposes with false hope given to recieve more grant money. anyway thanks all.


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guijr
(@guijr)
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What is the scientific name of his condition?

"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.


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jboldman
(@jboldman)
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is it duchenne or becker's MD otherwise i would not suggest it.

jb


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ridewya
(@ridewya)
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Posted by: jboldman
In duchenne or becker's MD, oxandrolone has been shown to improve protein anabolism. this was published last month. I would be careful to suggest it in the other forms of MD.

jb

=====

Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E530-9. Epub 2005 Nov 1. Related Articles, Links

Oxandrolone enhances skeletal muscle myosin synthesis and alters global gene expression profile in Duchenne muscular dystrophy.

I agree with JB Oxan have been proven to help athrophy even people with AIDS like Facial Wasting and Myalgia or Rhabdomyolisis. remember the golden rule : Less is more and more is less that goes for the dose

Another day, Another challange and Opportunity


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ridewya
(@ridewya)
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Posted by: guijr
What is the scientific name of his condition?

Rhabdomyolisis

Another day, Another challange and Opportunity


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