Yohimburn  

  RSS

GettinSwole
(@gettinswole)
Trusted Member
Joined: 1 year ago
Posts: 74
29/12/2018 7:06 am  

Is there any way that yohimburn could actually make you store more fat? I have only been using it for a couple of days but I have cleaned up my diet and also upped my cardio and I seem to be storing more fat in my abdominal region.

Any scientific reasoning that it coudl have a reverse effect Nandi? Jguns?


Quote
anabolicguru
(@anabolicguru)
Active Member
Joined: 1 year ago
Posts: 15
29/12/2018 8:01 am  

bro i dont believe so... what are you doing for cardio and what does your diet consist of are you eating alot of carbs?

" I LIVE THE LIFE I DO BECAUSE TO MANY PEOPLE ARE AFRAID TO "

WWW.GROWXXL.COM
" Where The Big Dogs Play "


ReplyQuote
GettinSwole
(@gettinswole)
Trusted Member
Joined: 1 year ago
Posts: 74
29/12/2018 9:59 am  

I'm eating about 2800cal per day. About 300g protein 300g carb and around 80g fat. Cardio is elliptical, walking on incline, etc. HR around 70-75% of Max for 30 minutes 4x/week.


ReplyQuote
anabolicguru
(@anabolicguru)
Active Member
Joined: 1 year ago
Posts: 15
29/12/2018 10:53 am  

all looks good what do you eat to get that much protein as im very interested in upping my protein intake significantly..

" I LIVE THE LIFE I DO BECAUSE TO MANY PEOPLE ARE AFRAID TO "

WWW.GROWXXL.COM
" Where The Big Dogs Play "


ReplyQuote
GettinSwole
(@gettinswole)
Trusted Member
Joined: 1 year ago
Posts: 74
29/12/2018 11:38 am  

JGUNS gets even more protein that I do. My intake depends a lot on my work schedule. What I ate today looked like this:
12PM-Roast Beef and Provolone on Wheat
16oz. Skim Milk
about 45g protein, 40g carbs

Post-Workout-4PM 60g Whey, 75g carbs

6PM-Myoplex mixed w/water
42g protein
24g carbs

8:30PM-8oz. Roasted Chicken, Potatoes, Steamed Veggies
about 60g protein, 60g carbs

12am-Pure Protein MRP bar
30g protein, 26g carb

3am-60g Whey, Handful of Mixed Nuts

Total-about 310g protein, 240 carbs

On days when I don't work I get a little more whole food.


ReplyQuote
anabolicguru
(@anabolicguru)
Active Member
Joined: 1 year ago
Posts: 15
29/12/2018 12:33 pm  

looks good bro i like that... i have a good one as well ill post tommorw for you i think youll like it...

" I LIVE THE LIFE I DO BECAUSE TO MANY PEOPLE ARE AFRAID TO "

WWW.GROWXXL.COM
" Where The Big Dogs Play "


ReplyQuote
anabolicguru
(@anabolicguru)
Active Member
Joined: 1 year ago
Posts: 15
29/12/2018 1:31 pm  

i tell you when i wanna keep water retention off i live and die by taraxatone this works so well for me to keep the water weight down..

" I LIVE THE LIFE I DO BECAUSE TO MANY PEOPLE ARE AFRAID TO "

WWW.GROWXXL.COM
" Where The Big Dogs Play "


ReplyQuote
GettinSwole
(@gettinswole)
Trusted Member
Joined: 1 year ago
Posts: 74
29/12/2018 2:19 pm  

I have the DF formula and I still feel like I'm holding fat/water.


ReplyQuote
InspectaPec
(@inspectapec)
New Member
Joined: 11 months ago
Posts: 1
29/12/2018 3:10 pm  
Posted by: GettinSwole
I have the DF formula and I still feel like I'm holding fat/water.

A friend of mine had the same concern. He used it 5 days on 2 days off until the bottle was empty. He would retain water "pockets" for the 5 days and then when he stopped using on the 2 days, it would dissapear. and so on and so forth until the bottle was gone.

I would recomend trying to get rid of every little bit of fat possible before using Yohimburn so you can really see the difference in results.


ReplyQuote
Nandi
(@nandi)
Estimable Member
Joined: 1 year ago
Posts: 190
29/12/2018 3:55 pm  

I would not expect much in the way of results from topical yohimbine. In one relatively recent study that compared the effects of several topical fat burners, everything worked EXCEPT yohimbine:

"All trials except yohimbine ointment gave significantly more girth loss from the treated thigh (p < 0.05 to p < 0.001)" (1)

However another trial did show that yohimbine helped to burn fat (2). Interestingly both trials were conducted by the same researcher. So the scientific basis for the claims that topical yohimbine burns is not strong.

Regarding estrogen and fat, in hamsters estrogen upregulates alpha 2 receptors (3) leading to reduced fat burning, but in humans estrogen downregulates lipoprotein lipase ( the major fat accumulating enzyme ) activity in fat cells and is thought to be a fat burning agent (4), with progesterone being responsible for fat accumulation in women's hips and thighs.

(1) Obes Res 1995 Nov;3 Suppl 4:561S-568S

Topical fat reduction.

Greenway FL, Bray GA, Heber D.

Department of Medicine, UCLA School of Medicine, Torrance, CA, USA.

(2) Clin Ther 1987;9(6):663-9 Related Articles, Links

Regional fat loss from the thigh in obese women after adrenergic modulation.

Greenway FL, Bray GA.

Department of Medicine, UCLA School of Medicine.

(3) Endocrinology 1986 Jun;118(6):2210-6

Estradiol treatment decreases the lipolytic responses of hamster white adipocytes through a reduction in the activity of the adenylate cyclase catalytic subunit.

Pecquery R, Leneveu MC, Giudicelli Y.

(4) Am J Obstet Gynecol 1998 Jan;178(1 Pt 1):101-7

Estrogen regulation of adipose tissue lipoprotein lipase--possible mechanism of body fat distribution.

Price TM, O'Brien SN, Welter BH, George R, Anandjiwala J, Kilgore M.

Department of Obstetrics and Gynecology, Greenville Hospital System, SC 29605, USA.


ReplyQuote
GettinSwole
(@gettinswole)
Trusted Member
Joined: 1 year ago
Posts: 74
29/12/2018 4:41 pm  

I saw that study. I figured I'd give it a shot for myself. Is there any way it could actually have a reverse effect and make me add abdominal fat though?


ReplyQuote
Nandi
(@nandi)
Estimable Member
Joined: 1 year ago
Posts: 190
29/12/2018 5:16 pm  

Not from what I know about the effects of yohimbine, GettingSwole.


ReplyQuote
monkeyballs
(@monkeyballs)
Eminent Member
Joined: 1 year ago
Posts: 38
29/12/2018 5:56 pm  
Posted by: Nandi12
I would not expect much in the way of results from topical yohimbine. In one relatively recent study that compared the effects of several topical fat burners, everything worked EXCEPT yohimbine:

"All trials except yohimbine ointment gave significantly more girth loss from the treated thigh (p < 0.05 to p < 0.001)" (1)

However another trial did show that yohimbine helped to burn fat (2). Interestingly both trials were conducted by the same researcher. So the scientific basis for the claims that topical yohimbine burns is not strong.

Regarding estrogen and fat, in hamsters estrogen upregulates alpha 2 receptors (3) leading to reduced fat burning, but in humans estrogen downregulates lipoprotein lipase ( the major fat accumulating enzyme ) activity in fat cells and is thought to be a fat burning agent (4), with progesterone being responsible for fat accumulation in women's hips and thighs.

(1) Obes Res 1995 Nov;3 Suppl 4:561S-568S

Topical fat reduction.

Greenway FL, Bray GA, Heber D.

Department of Medicine, UCLA School of Medicine, Torrance, CA, USA.

(2) Clin Ther 1987;9(6):663-9 Related Articles, Links

Regional fat loss from the thigh in obese women after adrenergic modulation.

Greenway FL, Bray GA.

Department of Medicine, UCLA School of Medicine.

(3) Endocrinology 1986 Jun;118(6):2210-6

Estradiol treatment decreases the lipolytic responses of hamster white adipocytes through a reduction in the activity of the adenylate cyclase catalytic subunit.

Pecquery R, Leneveu MC, Giudicelli Y.

(4) Am J Obstet Gynecol 1998 Jan;178(1 Pt 1):101-7

Estrogen regulation of adipose tissue lipoprotein lipase--possible mechanism of body fat distribution.

Price TM, O'Brien SN, Welter BH, George R, Anandjiwala J, Kilgore M.

Department of Obstetrics and Gynecology, Greenville Hospital System, SC 29605, USA.

I've always thought it was snake oil sold by the same people who claim that ALA is the greatest invention since the wheel.

You should post this over on elite, and then watch the cult members chase after you with burning torches and pitchforks. Last edited by monkeyballs on 01-02-2003 at 05:19 PM


ReplyQuote
Nandi
(@nandi)
Estimable Member
Joined: 1 year ago
Posts: 190
29/12/2018 6:28 pm  

You got me wondering, GettngSwole, if constant exposure to yohimbine could upregulate alpha 2 adrenergic receptors in fat cells, making fat burning more difficult. I did a quick search, and found that this effect has been studied in platelets, and indeed alpha 2 blockade ( this is what yohimbine does ) does upregulate those receptors.

This could potentially be red flag regarding topical yohimbine use. I'll see if I can find similar studies in fat cells.

Life Sci 1991;49(8):PL21-5

Effects of chronic alpha 2-adrenoceptor blockade on platelet and lymphocyte adrenoceptor binding in normal volunteers.

Glue P, Payvandi N, Kay G, Elliott JM, Nutt DJ.

Reckitt and Colman Psychopharmacology Unit, School of Medical Sciences, Bristol, UK.

Platelet and lymphocyte adrenoceptor binding was measured in 12 healthy male volunteers before and after 22 days treatment with the alpha 2-adrenoceptor antagonist idazoxan 40 mg tds. Platelet alpha 2-adrenoceptor number assessed by the agonist 3H-UK 14304 [correction of UK 14303] was significantly increased following idazoxan, with a smaller increase in antagonist binding (3H-rauwolscine). Lymphocyte beta-adrenoceptor number was unaltered by idazoxan, although the variance within the sample was significantly increased. Plasma MHPG levels were significantly reduced by chronic idazoxan. These data indicate upregulation of the platelet alpha 2-adrenoceptor in response to chronic blockade and suggest that this may reflect a similar change in presynaptic alpha 2-adrenoceptors which regulate norepinephrine release.

PS Monkeyballs. I just saw your post above. THIS is probably the abstract that would generate a firestorm at Elite


ReplyQuote
jboldman
(@jboldman)
Member Moderator
Joined: 1 year ago
Posts: 1054
29/12/2018 7:22 pm  

I have eschewed the use of topical yohimbine since I have experienced limited effectiveness unless you are very lean to start with. I actually made up my own mix out of dmso, YHcl, aminophyline, forskolin, and glycerol. I am still a fan of oral yhcl and find it to be very effective pre-exercise on an empty stomach.
==========

Med Hypotheses 2002 Jun;58(6):491-5 Related Articles, Links

Pre-exercise administration of yohimbine may enhance the efficacy of exercise training as a fat loss strategy by boosting lipolysis.

McCarty MF.

Pantox Laboratories, California 92109, USA.

The natural alpha-2 antagonist yohimbine promotes sympathetic activity by central as well as peripheral mechanisms, and yet in moderate doses dose not usually raise heart rate, increase blood pressure, or induce anxiety (in contrast to sympathomimetic drugs such as ephedrine). Administered prior to exercise, it boosts lipolysis and serum FFA levels both during and following exercise; blockade of adipocyte alpha-2 adrenoreceptors makes at least a modest contribution to this pro-lipolytic activity. These considerations suggest that pre-exercise administration of yohimbine will lower the respiratory quotient during and following exercise, thus promoting fat loss. Since yohimbine can potentiate postprandial insulin secretion, its bariatric benefits should be greatest if administered on a schedule that minimizes postprandial yohimbine activity. A possible synergism of yohimbine and caffeine should be explored. Pre-exercise yohimbine administration has the potential to down-regulate the lipoprotein lipase activity of visceral adipocytes, increase lipolysis in refractory gynoid fat depots, and improve the impaired lipolytic response to exercise in the elderly.


ReplyQuote
Share:

Please Login or Register