Prolactin & orgasm in men  

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Nandi
(@nandi)
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09/08/2018 3:56 pm  

Several studies have shown that elevated prolactin is the most consistent neuroendocrine marker of orgasm in men. Since men suffering from hyperprolactinemia generally have depressed libidos, it's been postulated that the prolactin released during orgasm in men is responsible for the "refractory period" during which another orgasm is difficult or impossible to achieve.

In support of this theory the abstract below summarizes a case study that showed a lack of prolactin release in a multi-orgasmic male.

Many people claim that bromocriptine and other dopaminergic agonists which lower prolactin increase their libido. I wonder if bromocriptine blocks the orgasm induced prolactin release as well as lowering basal prolactin levels, allowing a man to achieve multiple orgasms. (I have experimented with bromocriptine and never experienced this effect.)

Int J Impot Res. 2002 Apr;14(2):133-5.

Absence of orgasm-induced prolactin secretion in a healthy multi-orgasmic male subject.

Haake P, Exton MS, Haverkamp J, Kramer M, Leygraf N, Hartmann U, Schedlowski M, Krueger TH.

Department of Medical Psychology, University Clinic of Essen, Germany.

In several studies we have recently demonstrated that orgasm induces prolactin secretion in healthy males and females. This suggests that prolactin may form a feedback regulator of the refractory period following orgasm. To examine this position we investigated the prolactin response of a healthy multi-orgasmic male subject. Blood was drawn continuously during masturbation-induced orgasm. The prolactin response of the case-subject was compared with that of nine healthy adult men with a normal refractory period. The case-subject showed no prolactin response to three orgasms. Data from this multi-orgasmic subject support the hypothesized role of plasma prolactin in contributing to sexual-satiation mechanisms.


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sonic
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09/08/2018 4:44 pm  

I wonder why prolactin secretion would affect males but not females.

Hudson: "Hey Vasquez, You ever been mistaken for a man?" Vasquez: "No...have you?"
Aliens, 1983


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Nandi
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09/08/2018 5:34 pm  

In women, both oxytocin and prolactin are elevated post-orgasm, while in men, as noted above, only prolactin is consistently associated with orgasm. It's been postulated that the elevated post-coital oxytocin in women may offset the elevated prolactin, leading to a shorter refractory period.


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DSade
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09/08/2018 6:32 pm  

What is the effect of elevated Oxytocin in men post-orgasm? (meaning, can this BE artificially elevated in men, and has it been for purpose of testing?)


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sonic
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09/08/2018 7:17 pm  

If they could, they'd be selling it

Hudson: "Hey Vasquez, You ever been mistaken for a man?" Vasquez: "No...have you?"
Aliens, 1983


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sonic
(@sonic)
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09/08/2018 7:57 pm  

If they could, they'd be selling it

Hudson: "Hey Vasquez, You ever been mistaken for a man?" Vasquez: "No...have you?"
Aliens, 1983


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nox
 nox
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10/08/2018 5:02 am  
Posted by: DSade
What is the effect of elevated Oxytocin in men post-orgasm?

It should make you want to cuddle

In animal models oxytocin is responsible for pair-bonding. Also of note is that oxytocin levels are high during labor and may be responsible for the mother-child bond.

In the same animal models it seems that vasopressin is responsible for pair-bonds in males(1) - which is good because if oxytocin allowed men to go multiple rounds as well as form tighter bonds we'd never leave the bedroom.

(1) Adv Exp Med Biol. 1998;449:215-24. Oxytocin, vasopressin, and the neuroendocrine basis of pair bond formation.


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DSade
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10/08/2018 5:34 am  

Hmm..Oxytocin - the modern Love Potion No.9?


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nightop
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10/08/2018 6:33 am  

I think Lyle did a fairly good summary of much of the data on prolactin and T levels (in a Bromo followup article at qfac). The conclusion was that basically prolactin levels are best left in the middle/lower-middle of the normal physiologic range, in terms of T production. We know that prolactin is an important factor in maintaining LH-receptors, and such is one of the reasons why hypoprolactinemia does not correlate with healthy T production/levels.

Thus, using bromo or other dopamine agonist/drugs to increase libido and decrease refractory periods could potentially impair T production (and therefore reduce libido -- be counterproductive).

I'm wondering if one could strategically time/dose a short acting drug just around sex to reap the benefits while avoiding the problems, so to speak. One problem with this would of course be that doing so chronically could decrease LH receptors, if in fact the orgasm induced prolactin release is the primary factor in LH-r maintenance (meaning, compared to the non-orgasm related prolactin).


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Dante
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10/08/2018 7:13 am  

Vitex (a D2 agonist like Bromo) turned me into a sexually edacious creature.


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Nandi
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10/08/2018 8:08 am  

I confess, I had to pull out my dictionary for that one, Dante


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nightop
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10/08/2018 9:05 am  

so did i


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Dante
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10/08/2018 10:01 am  

It's (just about) obsolete, but it's a goodie :^) Just as Machiavellian replaced Mephistophelean, voracious did away with edacious.

Getting back to sex:

I really don't see the big fuss over bromo whether we're speaking of sex or dieting. If you want to attempt the creation of a lascivious beast, try vitex and yohimbine hcl.

One to several grams of vitex combined with 5-10 mgs of YHCL should do the trick. Both are very inexpensive, and are available OTC.

Avant should market a vitex supplement for men looking to put some size on their forearms.

My libido is naturally out of control and seemingly indestructible (even when my test levels were compromised, I was still unusually randy), and vitex actually made it worse. So I'd gather this could/should do wonders in the average individual.

Give it a try and be certain to use a quality product (Nature's Way, NOW, etc).


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Dante
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10/08/2018 10:58 am  
Posted by: Dante
My libido is naturally out of control and seemingly indestructible (even when my test levels were compromised, I was still unusually randy), and vitex actually made it worse. So I'd gather this could/should do wonders in the average individual.

BTW---I am not bragging. Since my Catholic upbringing turned me into an emotionally impaired sexual retard (i.e. I can't get laid) , I'd much rather subdue my cravings. I didn't try vitex for this purpose.

It's just interesting that it worked so well for a person who's already a maniac, so I'd expect this to work rather well for someone who's not.

On the female side of this, speaking of OTC options, YHCL combined with arginine looks promising.


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sonic
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10/08/2018 11:57 am  

can this combo overcome the "inability to orgasm" side effect of SSRIs? I really like being on them, but didn't want to give up sex (gee, I wonder why).

sonic

Hudson: "Hey Vasquez, You ever been mistaken for a man?" Vasquez: "No...have you?"
Aliens, 1983


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