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ADHD advice needed


BeLargeMini
(@belargemini)
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Joined: 4 years ago
Posts: 24
Topic starter  

I have run into a slight snag. I contracted Viral Meningitis about 1 month ago, and have recovered since. However, it seems that my ADHD has had a relapse (I was fine without meds). It all points to a dopaminergic problem (motivation, reward, focus, feeding). I have used wellbutrin in the past but it is ruled out due to PSVT sensitivity. Anyone aware of anything weaker and more selective to mesolimbic for dopamine?

I was looking into amineptine but it is not available, and could be too strong......

Relapse is most likely due to chronic administration of opiods (morphine for 1 week followed by 2 weeks of vicodin)....

Normally I would just let myself bounce back, but finals are in the next two weeks......

Thanks
BLM

Dropped the masters goal and math, accelrating program - going for the gold D.Sc or Ph.D
.... Performed my first surgery, patient survived, it was a great rush.


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53x12
(@53x12)
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Joined: 4 years ago
Posts: 24
 

Strattera a newer non-stim medication for add/adhd.

whatever it takes !!


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headdoc
(@headdoc)
Estimable Member
Joined: 4 years ago
Posts: 175
 

provigil. Or try 2-3 gms of ALCAR--or other formulation of cognitive factors or cognitive aminos OTC. Whenever I take analgesics for surgery, I'm foggy for a few weeks.

I have been on provigil for over a year w/o liver problems. Next month I'm doing some bloodwork and I'll see if I need to change that observation.

How are your studies coming along?

And we'll collect the moments one by one. I guess that's how the future's done. Feist, "Mushaboom", 2005


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BeLargeMini
(@belargemini)
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Joined: 4 years ago
Posts: 24
Topic starter  

I've actually tried strattera in the past, but my problem isn't with norepinephrine. Most symptoms point to a disorder of dopamine (I stabilized after my PSVT back in January, and didn't need anything for awhile).

Opiates have a really nasty inhibition on certain dopaminergic circuits in the brain (VTA/Nucleus Accumbens) which makes sense since the problems I expereienced revolved around motivation, feeding, focus, concentration - and of course the normal high of playing a guitar, lifting (lack of reward circuitry)....there is a theory that there exists a subset of ADHD that is either the result of a malfunction on D4, or D-transporter......It can stabilize but it has to be ultra clean....and it takes time.....It would be great if survector had been approved, but truth is it would have been highly addictive. So we went with a low dose of wellbutrin till I stabilize from the inhibitions caused by the morphine/vicodin combo.......

Studies are going really well, I am in talks with Brown University to stay....it would mean that I lose my Masters of Neuro and Math....but I could just skip to PhD on both counts....plus I am hearing some distressing news about home in New Orleans. My
home in new orleans survived but the outdoor mold count was 68,000 parts per cubic meter (epa start extremely high >50,000) with some buildings reporting upwards of a 600,000 count....It is the only allergy I actually have, so I am going to try to use it as grounds to stay here....

I got my grade for Akkadian (4,500 year old language, Old Babylonian) - A, and Medical Antrhopology should be an A......Neuro exam is Friday, and Calculus is Monday....so I am filling my time by teaching myself more number theory.....really
enjoy it, spent 23 hours on one problem, and it was awesome.
Plus I have professors begging me to stay, and giving me copies of their texts.....It is an honor, that I have never felt before...Not bad for a troublemaker in highschool where I was known by my GPA as 2.7

Grass isn't greener here though, 26 in a town of 18-22 yo is rather frightening......

I have been reading some of the research recently out of Brown's Neuro - highly recommend looking it up - it is called Braingate (essentially it is interpreting neural signals to predict limb movement, even in abscence of limb.....the possibilities are endless)....

I am also planning a company to do some revolutionary cutting edge Bio-Tech development. Going to be looking for cohorts who would be as addicted to the development as I am...

My ultimate goal is a do something that has never been done before, maybe get a field's medal or Nobel in the process....

BLM

Dropped the masters goal and math, accelrating program - going for the gold D.Sc or Ph.D
.... Performed my first surgery, patient survived, it was a great rush.


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headdoc
(@headdoc)
Estimable Member
Joined: 4 years ago
Posts: 175
 
Posted by: BeLargeMini
I've actually tried strattera in the past, but my problem isn't with norepinephrine. Most symptoms point to a disorder of dopamine (I stabilized after my PSVT back in January, and didn't need anything for awhile).

Opiates have a really nasty inhibition on certain dopaminergic circuits in the brain (VTA/Nucleus Accumbens) which makes sense since the problems I expereienced revolved around motivation, feeding, focus, concentration - and of course the normal high of playing a guitar, lifting (lack of reward circuitry)....there is a theory that there exists a subset of ADHD that is either the result of a malfunction on D4, or D-transporter......It can stabilize but it has to be ultra clean....and it takes time.....It would be great if survector had been approved, but truth is it would have been highly addictive. So we went with a low dose of wellbutrin till I stabilize from the inhibitions caused by the morphine/vicodin combo.......

Studies are going really well, I am in talks with Brown University to stay....it would mean that I lose my Masters of Neuro and Math....but I could just skip to PhD on both counts....plus I am hearing some distressing news about home in New Orleans. My
home in new orleans survived but the outdoor mold count was 68,000 parts per cubic meter (epa start extremely high >50,000) with some buildings reporting upwards of a 600,000 count....It is the only allergy I actually have, so I am going to try to use it as grounds to stay here....

I got my grade for Akkadian (4,500 year old language, Old Babylonian) - A, and Medical Antrhopology should be an A......Neuro exam is Friday, and Calculus is Monday....so I am filling my time by teaching myself more number theory.....really
enjoy it, spent 23 hours on one problem, and it was awesome.
Plus I have professors begging me to stay, and giving me copies of their texts.....It is an honor, that I have never felt before...Not bad for a troublemaker in highschool where I was known by my GPA as 2.7

Grass isn't greener here though, 26 in a town of 18-22 yo is rather frightening......

I have been reading some of the research recently out of Brown's Neuro - highly recommend looking it up - it is called Braingate (essentially it is interpreting neural signals to predict limb movement, even in abscence of limb.....the possibilities are endless)....

I am also planning a company to do some revolutionary cutting edge Bio-Tech development. Going to be looking for cohorts who would be as addicted to the development as I am...

My ultimate goal is a do something that has never been done before, maybe get a field's medal or Nobel in the process....

BLM

so I assume that Provigil would also be of little use.

And we'll collect the moments one by one. I guess that's how the future's done. Feist, "Mushaboom", 2005


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BeLargeMini
(@belargemini)
Eminent Member
Joined: 4 years ago
Posts: 24
Topic starter  

I am currently on a 6mg/24hr patch of EMSAM (selegiline patch)...wow, it is working and with only the small side effect of a slight headache......Tried provigil.......couldn't tolerate even 50mg....I am off label with the drug, but it is working wonders....I can read again, and I can still drink my glass of port of ice wine a week..

BLM

Dropped the masters goal and math, accelrating program - going for the gold D.Sc or Ph.D
.... Performed my first surgery, patient survived, it was a great rush.


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headdoc
(@headdoc)
Estimable Member
Joined: 4 years ago
Posts: 175
 

care to postulate the mechanisms of action that would be operable here?

And we'll collect the moments one by one. I guess that's how the future's done. Feist, "Mushaboom", 2005


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BeLargeMini
(@belargemini)
Eminent Member
Joined: 4 years ago
Posts: 24
Topic starter  

My theory is that something is causing rapid decay of dopamine, and there may be some involvement by PEA. Plus all serotonin drugs had a negative emotional impact, and strict SNRI or provigil (Alpha-adrenoagonist I believe the idea is type 1) resulted in only side effects and no benefit. Dopamine is involved with reward, motivation, and with voluntary motor control....I have been anxious, that was a side effect, that dissapeared with the new medication......Perhaps there is a motor control issue which affects my reading ability (IQ score was extremely high, yet I scored 30th percentile in reading, and 3rd percentile in foreign language apptitude ... plus 99th percentile in math).....
I believe that there is the possiblity of genetic cause (over expression of mao type b), result of using ritalin during critical years of youth (high dopamine transporter levels during maturation - yielding over expression of MAOb to maintain homestasis)....or there is something else going on, illness in early stages, or another neurotransmitter system....

I may have a research project proposition from some other ideas, but I am going to be attempting a grant proposal to pursue them...

Dropped the masters goal and math, accelrating program - going for the gold D.Sc or Ph.D
.... Performed my first surgery, patient survived, it was a great rush.


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53x12
(@53x12)
Eminent Member
Joined: 4 years ago
Posts: 24
 

Strattera a newer non-stim medication for add/adhd.

whatever it takes !!


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BeLargeMini
(@belargemini)
Eminent Member
Joined: 4 years ago
Posts: 24
Topic starter  

Well the main thing to remember is that my theory is not for all diagnosed ADHD.....I look at neuro disorders/diseases as a masquerade ball where many bodies wear the same face mask....they look alike on the surface but beneath the mask they are different.......

For now it is ADD with LD, but I have a feeling as neuroimaging capabilities expand that diagnoses might show something different in time...

I think there are more types of Attention disorders that are aching to be discovered and renamed....

Dropped the masters goal and math, accelrating program - going for the gold D.Sc or Ph.D
.... Performed my first surgery, patient survived, it was a great rush.


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headdoc
(@headdoc)
Estimable Member
Joined: 4 years ago
Posts: 175
 

I would very much appreciate imaging data to clarify the hypothesis testing that I feel my psycholgical/behavioral data do not clarify.

And we'll collect the moments one by one. I guess that's how the future's done. Feist, "Mushaboom", 2005


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BeLargeMini
(@belargemini)
Eminent Member
Joined: 4 years ago
Posts: 24
Topic starter  

I am working towards two PhDs one in a neurobiology specialty (unsure, most likely either diseases or neuroendocrinology), and the other is neuroimaging, so you and I are thinking along the same lines.....There is a new Dopamine Radioactive ligand coming out for SPECT diagnostics of ADD, but I have more quantum ideas so to speak. (also a ampakine modulator, ADHD smart drug? could have really negative side effects if it overpotentiates LTPs, but still is a first)

Dropped the masters goal and math, accelrating program - going for the gold D.Sc or Ph.D
.... Performed my first surgery, patient survived, it was a great rush.


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