Anabolic steroids impair the exercise-induced growth of the cardiac capillary bed.  

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Wicked Design
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26/06/2018 4:44 am  

1: Int J Sports Med. 2000 Aug;21(6):412-8. Related Articles, Links

Anabolic steroids impair the exercise-induced growth of the cardiac capillary bed.

Tagarakis CV, Bloch W, Hartmann G, Hollmann W, Addicks K.

Institute I of Anatomy, University of Cologne, Germany.

BACKGROUND: Concomitant application of anabolic-androgenic steroids and physical exercise can induce cardiac hypertrophy. These experiments investigate the still unknown response of the cardiac myocytes and capillaries to the combined influence of various anabolic steroids and muscular exercise. METHODS: Female SPF-NMRI mice were divided into the following groups: a) sedentary control, b) exercise (treadmill running); c) sedentary receiving Dianabol; d) exercise + Dianabol; e) exercise + Oral-Turinabol. After 3 and 6 weeks the left ventricular papillary muscles were studied morphometrically. Evaluated variables: minimal myocyte diameter, number of capillaries around a single myocyte, capillary density and intercapillary distance. RESULTS: Only the anabolic steroids + exercise groups showed a mild myocyte hypertrophy. In contrast, only exercise alone caused a significant increase of the capillary density after both experimental periods; e.g. capillary density after 6 weeks (capillaries/mm2, mean values +/- standard deviation, p < 0.05): control (4,272 +/- 287), exercise (5411 +/- 755), Dianabol(4,004 +/- 333), dianabol + exercise (4,076 +/- 403), oral-turinabol + exercise (4,053 +/- 306). Moreover, unlike all other regimens, only exercise alone shortened the intercapillary distance. Finally, exercise without drugs induced the greatest increase in the number of capillaries around a single myocyte. CONCLUSIONS: Anabolic steroids combined with exercise: 1) induce mild hypertrophy of the cardiac myocytes, 2) impair the cardiac microvascular adaptation to physical conditioning. The microvascular impairment may cause a detrimental alteration of the myocardial oxygen supply, especially during muscular exercise.

PMID: 10961516 [PubMed - indexed for MEDLINE]


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Big Cat
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26/06/2018 4:45 am  

Seems kind of stupid to leave out Testosterone in a trial like this ...

Good things come to those who weight.

The Big Cat is a researcher and theoreticist. His advice must never be taken in the stead of proper advice from a medical professional, it is entirely intended for research purposes.


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Nandi
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26/06/2018 4:46 am  

They published their results using testosterone in a separate paper. SOP to generate more publications from one study.


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Wicked Design
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26/06/2018 4:46 am  

Nandi the Test Propionate study noted mild myocyte hypertrophy.

Would this necessarily be a bad thing? I think it would be in cases of guys who don't come off but after androgens are discontinued wouldn't the cardiac capillary bed grow as normal thus restoring the balance in the heart???


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Nandi
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26/06/2018 4:47 am  

I don't think the hypertrophy itself is bad because exercise often leads to ventricular hypertrophy in humans, especially in highly trained athletes. But presumably there is a corresponding increased vascularization associated with exercise as well since elite athletes have normal or superior cardiac function.

The fact that the steroids impaired that vascularization is disturbing. I think your last question is the $60,000 one. And even if vascularization does catch up with the enlarged heart, for someone on a long cycle there could be a significant period where cardiac function is compromised. It's tough to put any kind of positive spin on these studies except to say that not having read the entire studies we don't know the steroid dosages they used, and we don't know if they did a followup exam to see if the hearts revascularized post-cycle. And we don't know if the same phenomenon would be seen in humans.

It certainly makes one sit up and take notice.


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Big Cat
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26/06/2018 4:48 am  

True, that last one is a bit of a dissapointment since it is the first inevitable effect that compromises health with testosterone use. With the only logical conclusion to be made that no steroid can be safely recommended in supraphysiological doses.

Good things come to those who weight.

The Big Cat is a researcher and theoreticist. His advice must never be taken in the stead of proper advice from a medical professional, it is entirely intended for research purposes.


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ready2explode
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26/06/2018 4:50 am  

Since we're on the subject of the heart...here's an article I just read
==================
Anabolic Steroids, Growth Hormone, and Hypertrophy of the Heart
It Takes Two to Tango

by Willem Koert, M.Sc.Willem Koert is a Dutch science writer.

Although his favourite subject is muscle enhancement and life extension, in his professional life he writes primarily about health, the food industry and biotechnology. In his spare time, he publishes Ergogenics, a newsletter on bodybuilding related science.

The debate on the effect of anabolic substances on the structure of the heart reached another phase, since Finnish scientists studied twenty local bodybuilders who had just finished their cycles. Steroids don�t damage the heart, the researchers found. But the combination of steroids and growth hormone does.

Context

Since the eighties scientists have been discussing whether steroids enlarge the heart, when several sports investigators learned steroid use was associated with enlargement of the left ventricular mass � the part of the heart that pumps oxygenated blood through the body. An overdeveloped left ventricle causes arrhythmia and, in severe cases, death. In 2001 Australian physicians found the hypertrophy in clean strength athletes and postulated that this condition was caused by weight training, not steroid use. They also found that the hypertrophy didn�t impair their subjects� health.

The new Finnish study, published in the International Journal of Sports Medicine in the summer of 2003, doesn�t contradict the Australian study. Nevertheless, it provides insight into the relationship between anabolic substances and heart hypertrophy.

Study

The Finnish ran an advertorial in a bodybuilding magazine on their project. Twenty bodybuilders, who had planned to do a cycle and bought their medication on the black market, responded. Before their cycle started the bodybuilders had their medication checked and analysed by the pharmacological department of the university. Not unnecessary, because up to fifty percent of the European black steroids may be counterfeited, according to the latest estimates.

Sixteen bodybuilders used steroids only. The weekly doses varied from a few hundred milligrams to more than thousand milligrams.

Four athletes stacked their steroids with growth hormone. All four used moderate dosages of two, three or four IU�s during four to six weeks. The growth hormone was injected once daily, mostly in the evening. In this group steroid doses were 1,3 times higher than in the steroids only group.

When their cycles ended, the bodybuilders had their hearts examined. The table below summarizes some results. The control group consisted of fifteen young males with active life styles who didn�t engage in weight training.

Results

Control(15) Steroids(16) Steroids + GH(4)
Heart rate 66 bpm 65 bpm 65 bpm
Systolic blood pressure 131 mmHg 131 mmHg 130 mmHg
Diastolic blood pressure 77 mmHg 76 mmHg 89 mmHg
Left ventricular weight 167 g 257 g 342 g
Ratio left ventricular weight: length 93 g/m 141 g/m 191 g/m
Relative wall thinkness 0,37 0,42 0,53
Ratio early peak flow velocity: peak atrial flow velocity (E/A ratio) 1,66 1,72 1,29

Steroids and the combination of steroids and growth hormone change the structure of the heart, the table suggests. But that doesn�t have any consequences for the cardiovascular health of at least the steroid users. Their diastolic blood pressure � reported to rise phenomenally in some steroid related medical horror-stories � was fine, and more interestingly, their E/A ratio improved. Cardiologists use the E/A ratio to measure the hearts efficiency. According to the table, in the steroids only group deterioration of the heart muscle didn�t occur.

But growth hormone, well, that is another story. The table speaks for itself. The higher steroid doses that the GH-users took can only explain a small part of the serious ventricular hypertrophy, the Finnish stress. They suspect that the lowering effect of androgens on the IGF-1-binding protein 3 concentrations causes the ventricular growth.

Discussion

So far not so good. But there is more. The Finnish discovered something very interesting about the nature of the relationship between anabolic aids and hypertrophy of the heart: it�s direct. For example, the Finnish asked their subjects for how many years they had been using steroids. The answers varied from one to twelve years. Statistically the relationship between lifetime steroid use and the E/A ratio was weak. On the other hand, the mean steroid dose of the present cycle was a strong predictor of variables like E/A ratio, ventricular weight of relative wall thickness.

This means that cycles don�t have a cumulative effect on heart hypertrophy. The Finnish discovered that even the pronounced impact of cycles with added growth hormone wears off. That became evident when they investigated an athlete three times: when he just finished a five weeks cycle of steroids and growth hormone, after a wash out period of 237 days, and just after he completed a steroids only cycle. The results are in the figure below.

Of course a study with twenty users is not conclusive. But the study suggests that

just like the Australians proved before, steroids are not as disastrous for the heart morphology as some agencies want you to believe; the combination with growth hormone does however add considerable cardiovascular risks to steroid cycles; and
the deleterious effects wear off during wash out periods.
Especially athletes in their late thirties and older should take their wash out periods seriously. The age of the subjects in the Finnish study ranged from 25 to 43. In this population age was the strongest predictor of the E/A ratio. The older they were, the lower their ratio ratio. (The Pearson�s correlation coefficient was �0.70. The coefficient of mean steroid dose and E/A ratio was �0.42.)

Sources

Karila TAM, Karjalainen JE, Mantysaari MJ, Viitasalo MT, Seppala TA. Anabolic Androgenic Steroids Produce Sose-Dependent Increase in Left Ventricular Mass in Power Athletes, and this Effect is Potentiated by Concomitant Use of Growth Hormone. Int J Sports Med 2003; 24: 337-343.

Sader MA, Griffiths KA, McCredie RJ, Handelsman DJ, Celermajer DS. Androgenic anabolic steroids and arterial structure and function in male bodybuilders. J Am Coll Cardiol. 2001 Jan;37(1):224-30.

"In any contest between power and patience, bet on patience."
~W.B. Prescott

"Only two things are infinite, the universe and human stupidity, and I'm not sure about the former."
~Albert Einstein


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Big Cat
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26/06/2018 4:51 am  

Since none of you originate from Dutch speaking countries, you guys are luckily not familiar with Willem Koert and his website ergogenics.nl. But it is the biggest pack of crap you have ever read.

Did you know his degree has nothing to do with physiology or anything of the like ? I don't know why he would bother mentioning it unless he was trying to profile himself as something more than he is. His site is sponsored by NeCeDo, a Dutch organization that "educates" (used as a clean term for demonizes) the use of banned anabolic substances. He often reports on studies he finds but cannot interpret in the least leading to greater misinformation than information. And because he does it all based on the same studies we all would use to substantiate our claims, he comes across as trustworthy to those who aren't versed in these matters.

Willem Koert is the worst kind of scum there is.

Good things come to those who weight.

The Big Cat is a researcher and theoreticist. His advice must never be taken in the stead of proper advice from a medical professional, it is entirely intended for research purposes.


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ready2explode
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26/06/2018 4:52 am  

Thats good to know...thanx for the info big cat...

"In any contest between power and patience, bet on patience."
~W.B. Prescott

"Only two things are infinite, the universe and human stupidity, and I'm not sure about the former."
~Albert Einstein


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mr pink
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26/06/2018 4:54 am  

I was doing a search on the study above and came across this thread and I was wondering if in the mean time more data has come on this subject?


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