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Questions About Steroids
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Topic starter
26/05/2019 7:08 am
J Clin Endocrinol Metab. 2005 Jun;90(6):3592-9.
Estrogen supplementation reduces whole body leucine and carbohydrate oxidation and increases lipid oxidation in men during endurance exercise.
Hamadeh MJ, Devries MC, Tarnopolsky MA.
Department of Pediatrics and Medicine, McMaster University Medical Center, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5.
Healthy active men exhibit higher rates of carbohydrate (CHO) and leucine oxidation and lower rates of lipid oxidation compared with their female counterparts both at rest and during moderate intensity endurance exercise. We postulated that this reduced dependence on amino acids as a fuel source in women was due to the female sex hormone estrogen. In a randomized, double-blind, placebo-controlled, cross-over design, we investigated the effect of supplementing 12 recreationally active men with estrogen on whole body substrate oxidation and leucine kinetics at rest and during moderate intensity endurance exercise. Subjects cycled for 90 min at an intensity of 65% maximum O(2) consumption after 8 d of either estrogen supplementation (2 mg 17beta-estradiol/d) or placebo (polycose). After a 2-wk washout period, they repeated the test after 8 d of the alternate treatment. On the test day, after a primed continuous infusion of l-[(13)C]leucine, O(2) consumption, CO(2) production, steady-state breath (13)CO(2), and plasma alpha-[(13)C]ketoisocaproate enrichments were measured at rest and at 60, 75, and 90 min during exercise in the postabsorptive state. Exercise increased energy expenditure more than 5-fold, CHO oxidation more than 6-fold, lipid oxidation more than 4-fold, and leucine oxidation 2.2-fold (all P < 0.0001), whereas it decreased the ratio of lipid to CHO oxidation by 50-70% (P = 0.003) compared with values at rest. Estrogen supplementation decreased respiratory exchange ratio during exercise (P = 0.03). Estrogen supplementation significantly decreased CHO oxidation by 5-16% (P = 0.04) and leucine oxidation by 16% (P = 0.01), whereas it significantly increased lipid oxidation by 22-44% (P = 0.024) at rest and during exercise. We conclude that estrogen influences fuel source selection at rest and during endurance exercise in recreationally active men, characterized by a reduced dependence on amino acids and CHO and an increased reliance on lipids as a fuel source.
dr frankenstein
26/05/2019 7:25 am
ant that would suggest to you that.......
jb
Topic starter
26/05/2019 7:50 am
ant that would suggest to you that.......jb
maybe, we may use estrogen.
my own levels are very low (near lower limits).
quote:
Exercise increased energy expenditure more than 5-fold, CHO oxidation more than 6-fold, lipid oxidation more than 4-fold
dr frankenstein
26/05/2019 8:17 am
I'd challenge you to find a bodybuilder who'd even consider it
Topic starter
26/05/2019 8:40 am
I'd challenge you to find a bodybuilder who'd even consider it
myself.
it should be an optimal level.
dr frankenstein
26/05/2019 8:58 am
Didn't we already have this discussion ? I remember nandi sent me that study shortly before his untimely passing...
Good things come to those who weight.
The Big Cat is a researcher and theoreticist. His advice must never be taken in the stead of proper advice from a medical professional, it is entirely intended for research purposes.
26/05/2019 9:17 am
Didn't we already have this discussion ? I remember nandi sent me that study shortly before his untimely passing...
I don't think OS was around then.
"In any contest between power and patience, bet on patience."
~W.B. Prescott
"Only two things are infinite, the universe and human stupidity, and I'm not sure about the former."
~Albert Einstein
Topic starter
26/05/2019 9:47 am
I don't think OS was around then.
correct and thanks!
quote:
Originally posted by nandi
There are other studies done directly in humans that contradict the in vitro research. In one study an estrogen patch was applied to the skin of women and a decrease in lipoprotein lipase (the primary enxyme responsible for deposition of fat) was noted. So factors other than alpha 2 receptors must be examined to get a more complete picture of fat physiology. In the article below, progesterone is cited as the culprit for the higher subcutaneous body fat seen in premenopausal women.
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i have done lab test of progesterone to womans and I do not obtain correlation.
when i use antiestrogen with womans be blockers or inhibitors it reduce subcutaneos fat,not visceral fat, I am going to deepen this.
quote:
Originally posted by ferrari
These findings demonstrate that estrogen attenuates the lipolytic response through up-regulation of the number of antilipolytic 2A-adrenergic receptors only in sc and not in visceral fat depots. Thus, our findings offer an explanation how estrogen maintains the typical female sc fat distribution because estrogen seems to inhibit lipolysis only in sc depots and thereby shifts the assimilation of fat from intraabdominal depots to sc depots.
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it has something of logic.
dr frankenstein
26/05/2019 10:17 am
erm....
OR, you could just do some cardio to increase lipid oxidation...
26/05/2019 10:46 am
Os wanna buy some estradiol patches?LOL
Seabiscuit Hogg is a fictious internet character. It is not recommended that you receive medical advice from fictious internet characters.
SBH :)
Topic starter
26/05/2019 11:10 am
Os wanna buy some estradiol patches?LOL
at my estradiol levels,maybe
around 8 pg/ml.
dr frankenstein
26/05/2019 11:30 am
Why not use low doses of something that aromatizes readily?
Seabiscuit Hogg is a fictious internet character. It is not recommended that you receive medical advice from fictious internet characters.
SBH :)
26/05/2019 11:54 am
say test!
jb
Topic starter
26/05/2019 12:25 pm
Why not use low doses of something that aromatizes readily?
i have used 1-2 gr of e test and my levels are the same 8 pg/ml,for 12-14 weeks.
dr frankenstein
26/05/2019 12:54 pm
and you're not using an ai?
Seabiscuit Hogg is a fictious internet character. It is not recommended that you receive medical advice from fictious internet characters.
SBH :)