Half life schedules and info
Different Drug HALF LIFE Schedules
Here are the half-lives for any of the following steroid esters:
Formate 1.5 days
Acetate 3 days
Propionate 4.5 days
Phenylpropionate 4.5 days
Butyrate 6 days
Valerate 7.5 days
Hexanoate 9 days
Caproate 9 days
Isocaproate 9 days
Heptanoate 10.5 days
Enanthate 10.5 days
Octanoate 12 days
Cypionate 12 days
Nonanoate 13.5 days
Decanoate 15 days
Undecanoate 16.5 days
For all you sust lovers out there note that the following esters and amounts are used:
Testonon uses the following amounts:
Note that sust and testonon are in fact different in one respect. Also note that the longest acting ester in these has a half-life of 15 days. As Andy noted previously, 1/2 the half-life should be the optimal point to begin therapy, thus 1 month (minimum) with testonon and sust.
I would like to point out another fact that arimidex has a half-life of 3 days. Thus an everyday administration is not neccessary
If I injected 500mg once a week, first off, it takes a few weeks to accumulate to a theraputic dose, but even then, there is some considerable flux in blood levels..
On day 27 for instance, 48.8 mg will have been de-esterified and through the system.
24 hrs after the weekly injection on day 28, 91.4mg will have been de-esterified and through the system. This is nearly a 100% increase in blood testosterone levels in one day.
On day 34, 50.4 mg will have been de-esterified. 24 hrs after the injection on day 35, 92.71mg will be released. Again, nearly a 100% increase in blood testosterone in one day.
Compare this with bi-weekly injections of 250mg...
at the end of D-13, 47.1mg will have been released,
24 hrs after the injection on D14, 66.07mg will have been released. THis is about a 40% increase in blood testosterone levels in one day.
on day 27, 58.8 mg are released and 24 hrs after the next shot of 250mg, 76.8mg are released. This is about a 30% increase in blood testosterone levels in one day.
As you can see, there is a considerable decrease in blood spiking with bi-weekly injections vs weekly. This value would decrease even more with EOD injections
Incedentally, with the bi-weekly injections, if 1000mg was taken on day one, and then the bi-weekly shots began on day 14 etc......
D-27, 61.7mg released, 24 hrs after the injection of 250mg on D-28, 79.97mg are released. this is a 30% increase in blood T levels in one day.
So front end loading doesn't ease the need to inject more often, it simply allows one to reach the theraputic level faster.
Hence the more even the blood concentration, the more gains and less sides
If you take this info into consideration using omna or sustanons it would appear that you would have a logistical nightmare on your hands.I often think sust's popularity is partialy due to the the mentality of "5 esters are better than 1!". The majority of the concentration of esters are in the larger, a little too large for my taste, as opposed to the lower. But due to the prop, you will always have a spike in blood levels.
Q.........Is it safer to allow your body a few weeks to adjust to the increased levels?
A............Well, here is kind of how I look at it. When we pop a bunch of orals or suspension with no ester...BAM! we get immediate raise in blood levels. This is really no different than a front load. And as mentioned, even in a front load of 1 single injection of triple the base cycle amount blood levels still do not reach the peak of what they will during the cycle. Even though there is a large amount in our systems, it is not usable due to the ester and our bodies can only hydrolize so much at a time as well. If raising blood levels fast was a detriment and so feared, then I would think people would be avoiding orals and no ester suspension like the plague.
Vertical numbers are the released testosterone testosterone levels while the horizon numbers are the days if you would look you'll find that the time taken to reach the half level or released Testosterone is between 4-6d which is 5d or the fifth day
Schulte-Beerbuhl M et al., Comparison of testosterone, dihydrotestosterone, luteinizing hormone, and follicle-stimulating hormone in serum after injection of Testosterone Enanthate or testosterone cypionate. Fertility and Sterility (1980) 33.2 : 201-203.
he didn't write the half-life but it's the time in which the level return to the basline only and not the half-life time
Undecylenate ester found in Equipoise having 11 carbon atoms while Decanoate 10, Enanthate 11 carbon atoms
by mean Undecylenate is 10% more in half-life than Decanoate and about 57% more than the enanthate ester
Enanthate ester half-life as everybody knows is 5days then multiply 5days with 157% = 8�days
then it will need about 8days to reach it's half-life
**Ref - Anon**
Disclaimer: yadda, yadda, yadda
Keeping it real
"I'm doin' a hundred on the highway
So if you do the speed limit, get the FUCK outta my way"
"The human body never ceases to amaze me. It is a brilliant machine, despite that fact that the majority of its owners are complete morons." (courtesy of monkeyballs)
Thanks bally! BTW, not a big deal but arimidex half life is closer to 2 days:
'ARIMIDEX' is a selective non-steroidal aromatase inhibitor. It inhibits the conversion of androstenedione to oestrone through the aromatase enzyme complex in peripheral tissues where oestrone is subsequently converted to oestradiol. In post-menopausal women, 'ARIMIDEX' at a daily dose of 1 mg produced oestradiol suppression of greater than 80%.
'ARIMIDEX' does not possess any progestogenic, androgenic or oestrogenic activity.
'ARIMIDEX' does not have any effect on cortisol or aldosterone secretion, measured before or after standard ACTH challenge testing.
Absorption of anastrozole is rapid and maximum plasma concentrations occur after two hours of dosing under fasted conditions. Anastrozole is eliminated slowly with a plasma elimination half-life of 40 to 50 hours. Food decreases the rate but not the extent of absorption. Approximately 90 to 95% of plasma anastrozole steady-state concentrations are attained after 7 daily doses. There is no evidence of time or dose-dependency of anastrozole pharmacokinetic parameters.
Anastrozole pharmacokinetics are independent of age in post-menopausal women.
Pharmacokinetics have not been studied in children.
Anastrozole is only 40% bound to plasma proteins.
Anastrozole is extensively metabolised by post-menopausal women with less than 10% of the dose excreted in the urine unchanged within 72 hours of dosing. Metabolism of anastrozole occurs by N-dealkylation, hydroxylation and glucuronidation. The metabolites are excreted primarily via the urine. Triazole, a major metabolite in plasma and urine, does not inhibit aromatase.
The apparent oral clearance of anastrozole in volunteers with mild stable hepatic cirrhosis or mild renal impairment was in the range observed in healthy volunteers.
As Test Enanthate's half life is 10.5 days, is it possible to cycle with just one shot per week?
P.S.: That's because the enanthate I have access, comes at the concentration of 350mg/ml... So, it's easier to be 350mg per week or 700mg per week, but I think 700mg is a lot...
Sorry for my english...