lipitor and your muscle  

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jboldman
(@jboldman)
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21/09/2019 12:34 am  

I have heard many times from guys that work out they do not take lipitor (or other statins) since they are worried about myalgia or muscle damage from the statin. I personally have not experienced this although it is a known but relatively rare side effect. This study took a look at this issue and found no deleterious effect fromtaking lipitor.

jb
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Effect of Atorvastatin on Energy Expenditure and Skeletal Muscle Oxidative Metabolism at Rest and During Exercise.Chung J, Brass EP, Ulrich RG, Hiatt WR.
1The Colorado Prevention Center, University of Colorado Health Sciences Center, Denver, Colorado, USA.

Statins are associated with adverse effects in skeletal muscle. This study tested the hypothesis that atorvastatin would increase the respiratory exchange ratio (RER) at rest and during exercise. Twenty-eight healthy subjects (mean age 52 years) were enrolled in a double-blind, placebo-controlled, randomized study of the effects of atorvastatin (40 mg/day) on whole body energetics over 8 weeks. Ventilatory gas exchange measurements, at rest and during bicycle ergometry, were used to assess muscle oxidative metabolism. Thirteen subjects from each treatment arm completed the study. Eight weeks of atorvastatin lowered plasma low-density lipoprotein cholesterol concentration but had no effect on resting or submaximal energy expenditure, RER, or calculated fatty acid oxidation rates. Atorvastatin did not affect maximal exercise oxygen consumption or the anaerobic threshold. Eight weeks of atorvastatin therapy was not associated with alterations in substrate oxidation, or muscle oxidative function at rest, or during exercise in healthy adults.Clinical Pharmacology & Therapeutics advance online publication 6 June 2007. doi:10.1038/sj.clpt.6100264.


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Bilter
(@bilter)
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21/09/2019 12:56 am  

JB,
are you taking a statin now??


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jboldman
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21/09/2019 1:14 am  

yes, lipitor. my last cholesterol was 89 TC 44 LDL and 30 HDL. I may switch to crestor to try to get my hdl up. It has come up 3 points.

jb


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Bilter
(@bilter)
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21/09/2019 1:44 am  
Posted by: jboldman
yes, lipitor. my last cholesterol was 89 TC 44 LDL and 30 HDL. I may switch to crestor to try to get my hdl up. It has come up 3 points.

jb

Wow, did the slow release niacin not work for you? I know you were trying it to keep lipids in line. How were your numbers prior to lipitor?


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jboldman
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21/09/2019 2:10 am  

i stopped it a while back as i was getting wired at 2000mg/night. i have started it back up at 1000mg/night to see how it goes, will check it in 6 weeks.

my numbers prior to lipitor were 240 tc ldl 160 hdl 27

jb


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Bilter
(@bilter)
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21/09/2019 2:39 am  

have you tried taking 1 asperin 30 minutes prior to the niacin?
I found this helps alot to keep sides down (actually eliminates them for me). But I only use 1000mg PD, at 2000mg I suspect I would have issues also.


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jboldman
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21/09/2019 3:01 am  

i was taking a 325 mg tab of aspirin 30 min prior. I am now doing 1000 mg with zero sides. i am going to see how this comes out on my next blood test and perhaps go up to 1500mg.

jb


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Dubbayoo
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21/09/2019 3:21 am  

Are you taking any OTC aids for cholesterol? red yeast rice, flax, niacin, etc. I have a life insurance physical coming up so I'm on a mission to get mine low. I have a kit on the way to measure it at home.


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jboldman
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21/09/2019 3:46 am  

best to try dietary first, no red meat, limited oil, no sat fat or transfat. i would not recommend red yeast rice since that can elevate your liver enzymes, same with niacin. polycosinol for hdl increase as well as cocoa powder (see recent thread). so, stay away from prepared foods, avoid sat fat, exercise and you should be good to go.

jb


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solysombra
(@solysombra)
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21/09/2019 4:09 am  

I'm happy about the cocoa powder!
However when I'm working out really hard I crave red meat (which was unusual for me).
Is there an explanation for the craving?
I would like to keep my ldl-hdl ration under control.
thanks.


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jboldman
(@jboldman)
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21/09/2019 4:30 am  

red meat is ok when consumed in reasonable quantities. Just make sure you cook up the lean cuts, avoid the fatty cuts except on special occasions. When i work out hard i get HUNGRY, the "what for" seems to be a personal thing and for me it varies but since i am usually watching my weight almost anything in quantity will do!

jb


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solysombra
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21/09/2019 4:47 am  

Thank you.
Since I sometimes have a tendency to underf-fuel my body, I do try to give it what it craves.
When I eat redmeat, it's always extra lean chopped beef--if it needs a little fat, I cook it in a spoon of olive or canola oil.
I tend to eat a pound a day if I eat it, but if not, I eat a huge amount of some other clean protein.
I tend to keep my protein intake quite high to avoid any catabolizing.

Any other foods to reduce ldl or raise hdl?
thank you.


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pSimonkey
(@psimonkey)
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21/09/2019 5:04 am  

Hey jb, what about gemfibrate? I have just started to look into it myself. Have you concidered it at all? If so what have you come up with?


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