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Tea Polyphenols


oswaldosalcedo
(@oswaldosalcedo)
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J Agric Food Chem. 2007 Jun 1.

Tea Polyphenol (-)-Epigallocatechin 3-Gallate Suppresses Heregulin-beta1-Induced Fatty Acid Synthase Expression in Human Breast Cancer Cells by Inhibiting Phosphatidylinositol 3-Kinase/Akt and Mitogen-Activated Protein Kinase Cascade Signaling.

Pan MH, Lin CC, Lin JK, Chen WJ.

dr frankenstein


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jboldman
(@jboldman)
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Joined: 6 years ago
Posts: 1448
 

help us out here?

jb


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oswaldosalcedo
(@oswaldosalcedo)
Estimable Member
Joined: 6 years ago
Posts: 243
Topic starter  

something lethargic lately.

i will do it.

dr frankenstein


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HugeDeep
(@hugedeep)
Member
Joined: 6 years ago
Posts: 175
 

Hmmm something to do with fatloss? I dunno.
HD

"SPES ET FIDES"


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oswaldosalcedo
(@oswaldosalcedo)
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Posts: 243
Topic starter  

Zero Speech (still with laziness) ....lol....

Front Biosci. 2007 Sep 1;12:4881-99.

Green tea polyphenols: biology and therapeutic implications in cancer.

Shankar S, Ganapathy S, Srivastava RK.

Department of Biochemistry, University of Texas Health Science Center at Tyler, Tyler, Texas 75703, USA.

Multiple lines of evidence, mostly from population-based studies, suggest that green tea consumption is associated with reduced risk of several human malignancies such as cancer and diabetes. Epigallocatechin-3-gallate (EGCG), a major polyphenol found in green tea, is a widely studied chemopreventive agent with potential anticancer activity. Green tea polyphenols inhibit angiogenesis and metastasis, and induce growth arrest and apoptosis through regulation of multiple signaling pathways. Specifically, EGCG regulates expression of VEGF, matrix metalloproteinases, uPA, IGF-1, EGFR, cell cycle regulatory proteins and inhibits NFk B, PI3-K/Akt, Ras/Raf/MAPK and AP-1 signaling pathways, thereby causing strong cancer chemopreventive effects. This review discusses the molecular mechanisms of green tea polyphenols and their therapeutic implications in cancer.

dr frankenstein


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