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Low-dose human chorionic gonadotropin maintains intratesticular testosterone in norma


razg
 razg
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Low-dose human chorionic gonadotropin maintains intratesticular Testosterone in norma

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Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression.

Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA.

In previous studies of testicular biopsy tissue from healthy men, intratesticular testosterone (ITT) has been shown to be much higher than serum testosterone (T), suggesting that high ITT is needed relative to serum T for normal spermatogenesis in men. However, the quantitative relationship between ITT and spermatogenesis is not known. To begin to address this issue experimentally, we determined the dose-response relationship between human chorionic gonadotropin (HCG) and ITT to ascertain the minimum dose needed to maintain ITT in the normal range. Twenty-nine men with normal reproductive physiology were randomized to receive 200 mg T enanthate weekly in combination with either saline placebo or 125, 250, or 500 IU hCG every other day for 3 wk. ITT was assessed in testicular fluid obtained by percutaneous fine needle aspiration at baseline and at the end of treatment. Baseline serum T (14.1 nmol/liter) was 1.2% of ITT (1174 nmol/liter). LH and FSH were profoundly suppressed to 5% and 3% of baseline, respectively, and ITT was suppressed by 94% (1234 to 72 nmol/liter) in the T enanthate/placebo group. ITT increased linearly with increasing hCG dose (P < 0.001). Posttreatment ITT was 25% less than baseline in the 125 IU hCG group, 7% less than baseline in the 250 IU hCG group, and 26% greater than baseline in the 500 IU hCG group. These results demonstrate that relatively low dose hCG maintains ITT within the normal range in healthy men with gonadotropin suppression. Extensions of this study will allow determination of the ITT concentration threshold required to maintain spermatogenesis in man.


I thought this may interest some of the HRT guys such as guijr and JB; I tried to attach the full study but it was apparently too large, and PDF is not permitted.


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jboldman
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this is the classic and oft quoted study that seems to be the definitive work on periodic low dose hcg. It is always a good read.

jb


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guijr
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Awesome classic paper razg, thanks a lot for trying to help.

"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.


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Bilter
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so in us TRT users what is the recomended dose / timimg? Certainly not 250IU EOD for ever. SHould we use it only once every couple of months? Recomendations are appriciated.
Good read Razq. Thankyou


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jboldman
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that is a good question and most likely revolves around whether or not you wish to maintain your fertility.

jb


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guijr
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Posted by: jboldman
that is a good question and most likely revolves around whether or not you wish to maintain your fertility.

jb

Besides that... whether or not we wish to maintain our boys full and down.

I don't know for sure yet, but I'm planning to use HCG only when I see that the boys are a bit atrophied (I mean not in a good shape) and always during a cycle.

"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.


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razg
 razg
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Apologies if my assumption is wrong, but does HRT not always cause atrophy, assuming fertility isn't an issue?


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jboldman
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well, you would think that to be the case however sometimes it does and sometimes it does not. i know guys that have been on supraphsiologic doses of test for years with no noticeable reported atrophy.

jb


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Restless
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It took me quite some time to notice any atrophy. I don't think in the first two years I actually noticed any. Now I do, and I'm planning on going back on HCG, with a period of HCG/HMG before that to induce spermatogenesis.


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oswaldosalcedo
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Re: Low-dose human chorionic gonadotropin maintains intratesticular Testosterone in norma

Posted by: razg
I thought this may interest some of the HRT guys such as guijr and JB; I tried to attach the full study but it was apparently too large, and PDF is not permitted.

Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression was posted by ready2expolde at:

hcg instead of test
post # 9

dr frankenstein


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guijr
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Re: Re: Low-dose human chorionic gonadotropin maintains intratesticular testosterone in norma

Posted by: oswaldosalcedo
Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression was posted by ready2expolde at:

hcg instead of test
post # 9

No, it's post number 12.

"The medals don't mean anything and the glory doesn't last. It's all about your happiness. The rewards are going to come, but my happiness is just loving the sport and having fun performing" ~ Jackie Joyner Kersee.


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oswaldosalcedo
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Re: Re: Re: Low-dose human chorionic gonadotropin maintains intratesticular testosterone in norma

Posted by: guijr
No, it's post number 12.

woow
faster!
......lol...............
yeah # 12.

dr frankenstein


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jboldman
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i think our approach must have been too subtle for osw.

jb


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