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l-carnitine revisited  

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jboldman
(@jboldman)
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16/09/2020 3:38 pm  

Mol Nutr Food Res. 2010 Oct 11. [Epub ahead of print]

Dietary L-carnitine alters gene expression in skeletal muscle of piglets.
Keller J, Ringseis R, Priebe S, Guthke R, Kluge H, Eder K.

Institute of Animal Nutrition and Nutrition Physiology, Justus-Liebig-Universität Gießen, Gießen, Germany.

Abstract
Scope: Carnitine improves protein accretion, muscle mass, and protein:fat accretion in piglets. The underlying mechanisms, however, are largely unknown.Methods and results: To gain insight into mechanisms through which carnitine exerts these effects, we fed piglets either a control or a carnitine-supplemented diet, and analyzed the transcriptome in skeletal muscle. Carnitine concentrations in plasma and muscle were about four-fold higher in the carnitine group when compared to the control group. Transcript profiling revealed 211 genes to be differentially expressed in muscle by carnitine supplementation. The identified genes were mainly involved in molecular processes such as cytoskeletal protein binding, insulin-like growth factor (IGF) binding, transcription factor activity, and insulin receptor binding. Identified genes with the molecular function transcription factor activity encoded primarily transcription factors, most of which were down-regulated by carnitine, including pro-apoptotic transcription factors such as proto-oncogene c-fos, proto-oncogene c-jun and activating transcription factor 3. Furthermore, atrophy-related genes such as atrogin-1, MuRF1, and DRE1 were significantly down-regulated by carnitine. IGF signalling and insulin signalling were identified as significantly up-regulated regulatory pathways in the carnitine group.Conclusion: Carnitine may have beneficial effects on skeletal muscle mass through stimulating the anabolic IGF-1 pathway and suppressing pro-apoptotic and atrophy-related genes, which are involved in apoptosis of muscle fibers and proteolysis of muscle proteins, respectively.

PMID: 20938991 [PubMed - as supplied by publisher]


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Seabiscuit Hogg
(@seabiscuit-hogg)
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16/09/2020 4:02 pm  

Good find jb. I believe it also upregulates ARs.

Seabiscuit Hogg is a fictious internet character. It is not recommended that you receive medical advice from fictious internet characters.

SBH :)


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Bananaman
(@bananaman)
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16/09/2020 4:29 pm  

LOL I hope they dont release those pigs into the wild, there could be chaos for the wild boar hunters in the black forest.

Studies like this are really useful- proving a mechanism shows there is something going on, and IMO re enforces the fact that its hard to interpret human studies because we aren't all genetically identical lab rats, so often a true result is missed. Its worth bearing that in mind before reading this slightly negative review of carnitine:

http://www.vanderbilt.edu/ans/psych...ogy/l-carni.htm

I've spoken to a very reputable sports scientist who is convinced carnitine has multiple benefits, if taken in the right form & the correct time. I'll post his paper once its published

cheers
BM


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Bananaman
(@bananaman)
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16/09/2020 4:58 pm  

URGENT UPDATE

just seen this news clip from Germany, maybe we should avoid carnitine:
http://www.youtube.com/watch?v=ZarBujE4Bis


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Seabiscuit Hogg
(@seabiscuit-hogg)
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16/09/2020 5:23 pm  

Damn! I take 1.5 grms ed. Didn't know it could make a hogg dangerous. Lol

Seabiscuit Hogg is a fictious internet character. It is not recommended that you receive medical advice from fictious internet characters.

SBH :)


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T5K
 T5K
(@t5k)
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16/09/2020 5:39 pm  

With the economy being down I've had to cut back on my athletics and have to be more focused on my career in order to keep bills paid. Some of the pre-workout rituals like pre-workout shakes I've established have made their way into my pre-work sessions and I make a shake with several things and L-carnitine is one of the things I swear by.

Anywho, back to the point. If your feeling bad it won't do anything but if I'm feeling good it'll help me stay in a good frame of mind while slaving away.


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oswaldosalcedo
(@oswaldosalcedo)
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16/09/2020 6:03 pm  

dont know....

Berl Munch Tierarztl Wochenschr. 2010 Jul-Aug;123(7-8):293-300.

[Relationships between endogenous carnitine content and growth as carcass traits in swine]

Engel P, Dzapo V.

Institut für Tierzucht und Haustiergenetik der Justus-Liebig-Universität, Giessen.

Abstract
In the present study on 29 growing female Deutsche Landrasse (DL) and Pietrain (Pi) pigs the relationship between endogenous carnitine content in plasma, in the blood lymphocytes and in the sceletal muscles with weight gain and carcass and meat quality is analysed. Significant correlations between carnitine content from rearing pigs to fattening pigs ((r)plasma rearing pig--plasma fattening pig = 0.48, (r)lymphocytes rearing pig--plasma fattening pig = 0.69) reveal that indiviual differences in the endogenous carnitine content sustain over the growth phase. The aforementioned correlation reflects a moderate reproducibility reflecting a heritability in a wider sense. Over all breeds a negative relation between the carnitine content and the weight gain was detected.These correlations within the breeds Pi and DL are different. The correlations between weight gain and carnitine in lymphocytes for fattening pigs within DL (r = -0.53 to -0.68) are significantly different from zero. Furthermore correlations between the carnitine content of lymphocytes or plasma of fattening pigs and in the sceletal the endogen fatty acid transport system had a small effect on the weight gain and a moderate effect on the carcass and meat quality of pigs.

dr frankenstein


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jboldman
(@jboldman)
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16/09/2020 6:26 pm  

but the study you quoted was based on endogenous levels, it could be that endo levels do not vary that much whereas exo creats a larger variance and hence effect.

jb


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oswaldosalcedo
(@oswaldosalcedo)
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16/09/2020 6:42 pm  
Posted by: jboldman
but the study you quoted was based on endogenous levels, it could be that endo levels do not vary that much whereas exo creats a larger variance and hence effect.

jb

not to counter point.

dr frankenstein


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liftsiron
(@liftsiron)
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16/09/2020 7:06 pm  

I take a couple como caps of l-c and coQ10 every day.

liftsiron is a fictional character and should be taken as such.


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53x12
(@53x12)
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16/09/2020 7:32 pm  

no comment...per say i know that l-carni is available, in ampules for injection. I've seen Vet and Human.

whatever it takes !!


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