Nicotine inhibits the in vitro production of interleukin 2 and tumour necrosis factor  

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Nandi
(@nandi)
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24/07/2018 5:36 am  

I posted an abstract on the anabolic forum on how Tumor Necrosis Factor alpha, TNF-alpha, exerts is muscle wasting effects by blocking production of IGF-1. Evidently nicotine suppresses TNF-alpha production:

Immunopharmacology 1996 Oct;35(1):47-51

Nicotine inhibits the in vitro production of interleukin 2 and tumour necrosis factor-alpha by human mononuclear cells.

Madretsma GS, Donze GJ, van Dijk AP, Tak CJ, Wilson JH, Zijlstra FJ.

Dept. of Pharmacology, Erasmus University, Rotterdam, The Netherlands.

Smoking protects against ulcerative colitis (UC), and treatment with nicotine patches has a beneficial symptomatic effect in patients with UC. To find an explanation for this response to nicotine in UC, we assessed the effects of nicotine on cytokine production by mononuclear cells (MNC). MNC were isolated from peripheral blood from healthy volunteers. Non-adherent MNC were preincubated with varying concentrations of nicotine or prednisolone for 24 h followed by addition of phytohemagglutinin (10 micrograms/ml). The concentrations of interleukin 2 (IL-2) and tumour necrosis factor-alpha (TNF alpha) in the supernatants were determined by ELISA. Nicotine as well as prednisolone caused a significant inhibition of IL-2 and TNF alpha production. The maximum inhibition caused by nicotine was about 50% of that caused by prednisolone and was reached at concentrations equivalent to nicotine levels measured in plasma of smokers. These results indicate that nicotine exerts its immunoregulatory role through modulation of the cytokine production by non-adherent mononuclear cells.


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monkeyballs
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24/07/2018 6:08 am  

Okay,
You've made your point. The science is fairly convincing. After your first post on nicotine uncoupling proteins, I did some research and there is a whole slew of applications for nicotine. Tourettes syndrome is treated with nicotine, and the US armed forces found that soldiers scored better on aptitude tests after smoking. Hence the way they used to push cigs like a smack dealer.

I will shitcan my emotional hessitation to use any form of nicotine and perhaps chew a piece of gum occasionally.

Any tips on how/when I should chew my narcotics?

Also, If IL-2 is supposedly so good to supplement, then wouldn't something that inhibits it's production be a detriment?


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monkeyballs
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24/07/2018 7:24 am  
Posted by: Nandi12
. If you have arthritis, IL-2 is your enemy becuase it is proinflammatory in synovial tissue.

It's a no go for me. As you know, I'm Vioxx dependant.

A ride up emigration canyon fires me up to the point where I offten have to take 50mgs while I'm still on my bike.

Although it is tendonosis, not tendonitits. Perhaps the two have differant mechanisms with relation to IL-2?


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Nandi
(@nandi)
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24/07/2018 8:04 am  

I wonder what the effects of blocking PDGFRbeta on tendinosis would be?

Rheumatology (Oxford) 2001 Mar;40(3):256-61 Related Articles, Links

Increased cell proliferation and associated expression of PDGFRbeta causing hypercellularity in patellar tendinosis.

Rolf CG, Fu BS, Pau A, Wang W, Chan B.

Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong.

OBJECTIVE: This study assessed cellularity in patellar tendinosis with respect to cell proliferation and the expression of platelet-derived growth factor receptor beta (PDGFRbeta). METHODS: Surgical samples were taken from 11 patients fulfilling criteria of patellar tendinosis and from 12 matched controls. Standard immunohistochemistry methods were used to detect expression of PDGFRbeta and proliferation cell nuclear antigen (PCNA). Results were analysed by computer-assisted microscopy. Tendon cells were isolated from nine tendinosis and eight control tissues for cell culture. RESULTS: Increased cellularity (P<0.001) was observed in tendinosis tissues compared with controls, and also a higher proliferative index (P:<0.001). Increased expression of PDGFRbeta was demonstrated (P<0.001). Cultured tendinosis cells showed a higher proliferation rate than controls (P<0.001). This was maintained when the cells were cultured under various conditions of serum supplementation (P<0.01). Tendinosis cells also showed a higher proliferation rate (P<0.01) in medium containing 10 ng/ml PDGF. CONCLUSION: Hypercellularity in patellar tendinosis is caused by increased cell proliferation and is associated with increased expression of PDGFRbeta.


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Nandi
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24/07/2018 9:38 am  

I know you mean no disrespect, Ike. I've said I have a smoke with my cocktail before dinner, but I don't believe smoking is the way to get the most from nicotine. I much prefer smoking over patches or gum strictly from a hedonistic perspective: there is a more pleasurable nicotine rush when you smoke.

Nicotine is one of God's gifts to mankind, along with morphine and a few other compounds. I find it almost miraculous that something that evolved to kill bugs trying to eat the plants can have such diverse effects in humans.

The other big question I would ask God if given the chance is why math works. How is it that something that is constructed purely from the human mind based on a set of axioms can describe nature out to as many decimal places as one cares to pursue it?


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monkeyballs
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24/07/2018 10:18 am  
Posted by: Nandi12
The other big question I would ask God if given the chance is why math works. How is it that something that is constructed purely from the human mind based on a set of axioms can describe nature out to as many decimal places as one cares to pursue it?

Math, science, and all other pursuits of acedemia are an attempt to either confirm or dispell the existance of god. By the tennants of science, if god exists, eventually it will be proven. As I'm sure you know, it can never be disproven...only perpetuated as it now.

Science and religion are inherently opposed to one another, as the notion of "faith" is incongrunet with the tennents of the scientific method.

Mechanism...

Back to the nicotine, arsenic is a "gift" from god as well.


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saint808
(@saint808)
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24/07/2018 10:54 am  

read the physics of immortality by frank j tipler... it's a mathematic look at god and he claims to prove the existance of god... kinda neat.

Disclaimer:
saint808 is presenting fictitious opinions and does in no way, shape or form encourage, use nor condone the use of any illegal substances or the use of legal substances in an illegal manner. The information discussed is strictly for entertainment purposes only and shall not take the place of qualified medical advice.

To quote Oscar Wilde, "They say we destroy the things we love, but really the things we love destroy us."

It's strange, how laughter looks like crying, with no sound and rain drops taste like tears, without the pain.


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Nandi
(@nandi)
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24/07/2018 11:37 am  

quote:


Back to the nicotine, arsenic is a "gift" from god as well.


Now you are being just plain cynical. Obviously nicotine can't be put in the same category as morphine; I admit to taking the analogy too far. Nicotine can certainly provide pleasure. It can pick you up when you are down, and relax you when you are stressed. Not many drugs have such a spectrum of effects.

Morphine is the true gift, in terms of the suffering it has ameliorated throughout the ages, from a GI with his intestines hanging out in a muddy trench, to a cancer patient who would otherwise commit suicide out of sheer suffering from pain.

Tipler's stuff is interesting if speculative. He writes excellent intro physicis texts. I taught out of one before I left academics to prostitute myself to the almighty dollar of the private sector.


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Nandi
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24/07/2018 1:29 pm  

quote:


I mostly had queer socialists as my professors.


I had my share of those in the obligatory liberal arts classes I had to take (and which were probably good for me in hindsight). I went to school in queer/socialist Mecca: Berkeley. There were no girls in the physics and engineering classes, and all the ones in the social science classes were militant lesbians.

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jboldman
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24/07/2018 2:11 pm  

Sorry to bring a downer to this heady discussion but calling nicotine a gift from god is, as you pointed out nandi, carrying it a bit too far. last I checked, Smoking and smoking related illness were the number one causes of death(or at least close to the top) in this country! Although there may be some benefits the risk of smoking far outweighs any benefits. As far as dieting with the patch, damn, they are expensive, i would just try a little more cardio and diet adjustments unless you are independently wealthy. According to my wife(formerly an RN at the local hospital) dying from lung cancer is one of the most painful and traumatic ways to meet your maker. On an intellectual level I hear what you are saying but the massive health problems caused by smoking are just to hard for me to ignore.


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1fast400
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24/07/2018 2:48 pm  

I assume the use of it would be temporary (i.e. cutting phases) and not used constantly. With that in mind I don't think the ailments are a factor here.

I've looked into carrying nicotine on the site, just trying to find the best place to buy it.


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Nandi
(@nandi)
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24/07/2018 3:43 pm  

quote:


I assume the use of it would be temporary (i.e. cutting phases) and not used constantly. With that in mind I don't think the ailments are a factor here.


Now here is a reasonable man. I think some of the other contributors to this thread are having a hard time dissociating occasional nicotine use from chronic smoking.

Considering that many people use DNP, clen (which in animals has shown damaging effects on the heart), T3 and god knows what else for cutting, nicotine seems pretty benign. It has just become a victim of the political correctness in this country that makes me ill.

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nice6pac
(@nice6pac)
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06/08/2018 4:27 pm  

how would you suggest using nicotine and how do you think it would be beneficial please cite as ia m curious


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